Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	12	563	11q12.3	SLC22A6	solute carrier family 22 member 6
Mouse	12	545	19 5.44 cM	Slc22a6	solute carrier family 22 (organic anion transporter), member 6
Rat	11	551	1q43	Slc22a6	solute carrier family 22 member 6

Previous and Unofficial Names

PAH transporter | Renal organic anion transporter 1 | PAHT | ROAT1 | solute carrier family 22 (organic anion transporter) member 6 | NKT | solute carrier family 22 (organic anion transporter), member 6 | solute carrier family 22 (organic anion transporter)

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC22A6 (Hs)
RESOLUTE	SLC22A6 (Hs)
Other databases
Alphafold	Q4U2R8 (Hs), Q8VC69 (Mm), O35956 (Rn)
ChEMBL Target	CHEMBL1641347 (Hs), CHEMBL5653 (Mm), CHEMBL1777665 (Rn)
DrugBank Target	Q4U2R8 (Hs)
Ensembl Gene	ENSG00000197901 (Hs), ENSMUSG00000024650 (Mm), ENSRNOG00000018215 (Rn)
Entrez Gene	9356 (Hs), 18399 (Mm), 29509 (Rn)
Human Protein Atlas	ENSG00000197901 (Hs)
KEGG Gene	hsa:9356 (Hs), mmu:18399 (Mm), rno:29509 (Rn)
OMIM	607582 (Hs)
Pharos	Q4U2R8 (Hs)
UniProtKB	Q4U2R8 (Hs), Q8VC69 (Mm), O35956 (Rn)
Wikipedia	SLC22A6 (Hs)

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference uric acid Hs - - 3 aminohippuric acid Hs - tenofovir Hs - - 1 non-steroidal anti-inflammatory drugs Hs -

Stoichiometry
Unknown

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference probenecid Hs Inhibition 4.9 pIC50 2 ⤷ pIC50 4.9 (IC50 1.25x10-5 M) Inhibition of urate transport by human SCL22A6. [2]