Organic anion transporter 1 | Organic anion transporters (OATs) | IUPHAR/BPS Guide to PHARMACOLOGY

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Organic anion transporter 1

Target not currently curated in GtoImmuPdb

Target id: 1025

Nomenclature: Organic anion transporter 1

Abbreviated Name: OAT1

Systematic Nomenclature: SLC22A6

Family: Organic anion transporters (OATs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 563 11q12.3 SLC22A6 solute carrier family 22 member 6
Mouse 12 545 19 5.44 cM Slc22a6 solute carrier family 22 (organic anion transporter)
Rat 11 551 1q43 Slc22a6 solute carrier family 22 member 6
Previous and Unofficial Names
PAH transporter | Renal organic anion transporter 1 | PAHT | ROAT1 | NKT | solute carrier family 22 (organic anion transporter) member 6 | solute carrier family 22 (organic anion transporter), member 6 | solute carrier family 22 (organic anion transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A6 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
uric acid Hs - - 2
aminohippuric acid Hs -
non-steroidal anti-inflammatory drugs Hs -

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
probenecid Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.25x10-5 M) Inhibition of urate transport by human SCL22A6. [1]


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1. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int., 63 (1): 143-55. [PMID:12472777]

2. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr. Opin. Nephrol. Hypertens., 27 (4): 305-313. [PMID:29847376]


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