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Organic anion transporter 3

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Target not currently curated in GtoImmuPdb

Target id: 1027

Nomenclature: Organic anion transporter 3

Abbreviated Name: OAT3

Systematic Nomenclature: SLC22A8

Family: Organic anion transporters (OATs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 11 542 11q12.3 SLC22A8 solute carrier family 22 member 8
Mouse 11 537 19 A Slc22a8 solute carrier family 22 (organic anion transporter), member 8
Rat 11 536 1q43 Slc22a8 solute carrier family 22 member 8
Previous and Unofficial Names Click here for help
OCT3 | organic anion transporter 3 | solute carrier family 22 member 8 | solute carrier family 22 (organic anion transporter), member 8 | solute carrier family 22 (organic anion transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A8 (Hs)
RESOLUTE SLC22A8 (Hs)
Other databases
Alphafold Q8TCC7 (Hs), O88909 (Mm), Q9R1U7 (Rn)
ChEMBL Target CHEMBL1641348 (Hs), CHEMBL2073672 (Mm), CHEMBL2073666 (Rn)
DrugBank Target Q8TCC7 (Hs)
Ensembl Gene ENSG00000149452 (Hs), ENSMUSG00000063796 (Mm), ENSRNOG00000018086 (Rn)
Entrez Gene 9376 (Hs), 19879 (Mm), 83500 (Rn)
Human Protein Atlas ENSG00000149452 (Hs)
KEGG Gene hsa:9376 (Hs), mmu:19879 (Mm), rno:83500 (Rn)
OMIM 607581 (Hs)
Pharos Q8TCC7 (Hs)
UniProtKB Q8TCC7 (Hs), O88909 (Mm), Q9R1U7 (Rn)
Wikipedia SLC22A8 (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
cimetidine Hs - 3
ochratoxin A Hs - 3
uric acid Hs - - 4
estrone-3-sulphate Hs - 3
aminohippuric acid Hs - 3
tenofovir Hs - - 1
Stoichiometry Click here for help
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cefalotin Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.6 pIC50 5
⤷ pIC50 7.6 (IC50 2.6x10-8 M) [5]
NPT520-34 Small molecule or natural product Immunopharmacology Ligand Hs Inhibition 6.6 pIC50 2
⤷ pIC50 6.6 (IC50 2.5x10-7 M) [2]
Description: Measuring inhibition of [3H]-PAH transport by hOAT3.

References

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1. Fernandez-Fernandez B, Montoya-Ferrer A, Sanz AB, Sanchez-Niño MD, Izquierdo MC, Poveda J, Sainz-Prestel V, Ortiz-Martin N, Parra-Rodriguez A, Selgas R et al.. (2011) Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat, 2011: 354908. [PMID:21716719]

2. Khan A, Johnson R, Wittmer C, Maile M, Tatsukawa K, Wong JL, Gill MB, Stocking EM, Natala SR, Paulino AD et al.. (2021) NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease. Brain, 144 (12): 3692-3709. [PMID:34117864]

3. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem, 274 (19): 13675-80. [PMID:10224140]

4. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]

5. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol, 438 (3): 137-42. [PMID:11909604]

Contributors

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