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Organic anion transporter 1

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Target not currently curated in GtoImmuPdb

Target id: 1025

Nomenclature: Organic anion transporter 1

Abbreviated Name: OAT1

Systematic Nomenclature: SLC22A6

Family: Organic anion transporters (OATs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 563 11q12.3 SLC22A6 solute carrier family 22 member 6
Mouse 12 545 19 5.44 cM Slc22a6 solute carrier family 22 (organic anion transporter), member 6
Rat 11 551 1q43 Slc22a6 solute carrier family 22 member 6
Previous and Unofficial Names Click here for help
PAH transporter | Renal organic anion transporter 1 | PAHT | ROAT1 | solute carrier family 22 (organic anion transporter) member 6 | NKT | solute carrier family 22 (organic anion transporter), member 6 | solute carrier family 22 (organic anion transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A6 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
uric acid Hs - - 3
aminohippuric acid Hs -
tenofovir Hs - - 1
non-steroidal anti-inflammatory drugs Hs -
Stoichiometry Click here for help
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
probenecid Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 4.9 pIC50 2
pIC50 4.9 (IC50 1.25x10-5 M) Inhibition of urate transport by human SCL22A6. [2]

References

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1. Fernandez-Fernandez B, Montoya-Ferrer A, Sanz AB, Sanchez-Niño MD, Izquierdo MC, Poveda J, Sainz-Prestel V, Ortiz-Martin N, Parra-Rodriguez A, Selgas R et al.. (2011) Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat, 2011: 354908. [PMID:21716719]

2. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int, 63 (1): 143-55. [PMID:12472777]

3. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]

Contributors

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