capadenoson [Ligand Id: 11221] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3235279 (Bay-684986, BAY 68-4986, BAY-68-4986, Capadenoson) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranes by competition association assay | B | 8.85 | pKi | 1.4 | nM | Ki | Eur J Med Chem (2015) 101: 681-691 [PMID:26210506] |
| ChEMBL | Agonist activity at human adenosine A1 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay | F | 8.96 | pEC50 | 1.1 | nM | EC50 | Eur J Med Chem (2015) 101: 681-691 [PMID:26210506] |
| GtoPdb | - | - | 10 | pEC50 | 0.1 | nM | EC50 | Purinergic Signal (2012) 8: 91-9 [PMID:22081230] |
| ChEMBL | Agonist activity at adenosine A1 receptor (unknown origin) expressed in CHO cells assessed as increase in intracellular cAMP level by RIA | F | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (2014) 57: 3213-3222 [PMID:24669958] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
