GR 128107 [Ligand Id: 1348] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3260983 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 365-75 [PMID:9089668]; Br J Pharmacol (1999) 126: 1237-45 [PMID:10205014] |
| ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells | B | 7.04 | pKi | 90.4 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
| ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| GtoPdb | - | - | 9.1 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 365-75 [PMID:9089668]; Br J Pharmacol (1999) 126: 1237-45 [PMID:10205014] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
