ChEMBL ligand: CHEMBL1747 (Vantobra, Vantobra (previously tobramycin pari), Tobralex, Bramitob, Tobrex, Nebcin, Tobramycin component of tobradex st, Tobramycine, Tobi podhaler, Kitabis pak, Tobramycin component of zylet, Bethkis, NSC-180514, Nebramycin factor 6, Tobramicina, Nebramycin vi, 47663, Tymbrineb, Tobramycin component of tobradex, Tobi, Aktob, Nebris, Nebicin, Tobramycin component of tobrasone, Tobramycin, Tobravisc)
heparanase/Heparanase in Human [ChEMBL: CHEMBL3921] [GtoPdb: 2996] [UniProtKB: Q9Y251] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3852] [UniProtKB: Q77Y21] There should be some charts here, you may need to enable JavaScript!
TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
heparanase/Heparanase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3921] [GtoPdb: 2996] [UniProtKB: Q9Y251]
ChEMBL	Inhibition of N-terminal His-tagged recombinant human heparanase (36 to 543 residues) extracted from CHO cells using Biotin-heparin sulfate-Eu cryptate as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by TR-FRET assay	B	6.05	pIC50	900	nM	IC50	J Med Chem (2025) 68: 12708-12732 [PMID:40500735]
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3852] [UniProtKB: Q77Y21]
ChEMBL	Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy	F	5.39	pKd	4110	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1127-1131 [PMID:11354359]
TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543]
GtoPdb	-	-	4.29	pEC50	50970	nM	EC50	FASEB J (2019) 33: 501-517 [PMID:30011231]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]