GtoPdb Ligand ID: 756

Synonyms: macrophage inflammatory protein-1α | MIP-1α
Comment: CCL3 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1α or MIP-1α. It acts in a dimer with CCL4 (MIP-1β) [1].
Species: Human
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
macrophage inflammatory protein-1α | MIP-1α
Medical Relevance
A variation in the MIP-1α gene (specifically, a polymorphism MIP-1α -906 (TA)(6)/(TA)(6) ) may increase susceptibility to ulcerative colitis [5]
Gene symbol Gene name Species Precursor protein name Synonyms
CCL3 C-C motif chemokine ligand 3 Human C-C motif chemokine 3 chemokine (C-C motif) ligand 3, G0S19-1, LD78ALPHA, MIP-1-alpha, SCYA3, small inducible cytokine A3 (homologous to mouse Mip-1a)
Database Links
Ensembl Gene ENSG00000006075 (Hs)
Entrez Gene 6348 (Hs)
GtoPdb PubChem SID 135651684
Human Protein Atlas ENSG00000006075 (Hs)
Immunopaedia Search CCL3
OMIM 182283
RefSeq Protein NP_002974
UniProtKB P10147 (Hs)
Wikipedia CCL3 (Hs)