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Synonyms: macrophage inflammatory protein-1α | MIP-1α
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CCL3 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1α or MIP-1α. It acts in a dimer with CCL4 (MIP-1β) [1].
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Ligand families/groups | Chemokines |
| Synonyms |
| macrophage inflammatory protein-1α | MIP-1α |
| Medical Relevance | |
| A variation in the MIP-1α gene (specifically, a polymorphism MIP-1α -906 (TA)(6)/(TA)(6) ) may increase susceptibility to ulcerative colitis [5] | |
| Gene/Precursor |
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| Database Links |
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| Specialist databases | |
| GPCRdb Ligand | CCL3 |
| Other databases | |
| Ensembl Gene | ENSG00000006075 (Hs) |
| Entrez Gene | 6348 (Hs) |
| GtoPdb PubChem SID | 135651684 |
| Human Protein Atlas | ENSG00000006075 (Hs) |
| Immunopaedia Search | CCL3 |
| OMIM | 182283 |
| RefSeq Protein | NP_002974 |
| UniProtKB | P10147 (Hs) |
| Wikipedia | CCL3 (Hs) |
