Citrusinine II [Ligand Id: 11377] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL465847 (Citrusinine-Ii) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
| ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots | B | 5.38 | pKi | 4200 | nM | Ki | Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783] |
| GtoPdb | Inhibition of human recombinant cathepsin V. | - | 5.38 | pKi | 4200 | nM | Ki | Bioorg Med Chem (2011) 19: 1477-81 [PMID:21277783] |
| ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.48 | pIC50 | 33000 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake | F | 4.57 | pIC50 | 27100 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 after 72 hrs by [3H]hypoxanthine uptake | F | 4.69 | pIC50 | 20500 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.7 | pIC50 | 20100 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
| GtoPdb | - | - | 4.91 | pIC50 | 12430 | nM | IC50 | Br J Pharmacol (2021) 178: 1669-1683 [PMID:33501656] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
