Citrusinine II [Ligand Id: 11377] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL465847 (Citrusinine-Ii)
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  • TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911]
ChEMBL Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots B 5.38 pKi 4200 nM Ki Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783]
GtoPdb Inhibition of human recombinant cathepsin V. - 5.38 pKi 4200 nM Ki Bioorg Med Chem (2011) 19: 1477-81 [PMID:21277783]
ChEMBL Inhibition of human recombinant cathepsin V expressed in Pichia pastoris B 5 pIC50 10000 nM IC50 Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake F 4.48 pIC50 33000 nM IC50 J Nat Prod (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake F 4.57 pIC50 27100 nM IC50 J Nat Prod (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 after 72 hrs by [3H]hypoxanthine uptake F 4.69 pIC50 20500 nM IC50 J Nat Prod (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake F 4.7 pIC50 20100 nM IC50 J Nat Prod (2001) 64: 1221-1223 [PMID:11575960]
TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8]
GtoPdb - - 4.91 pIC50 12430 nM IC50 Br J Pharmacol (2021) 178: 1669-1683 [PMID:33501656]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]