Citrusinine II [Ligand Id: 11377] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL465847 (Citrusinine-Ii) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
| ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots | B | 5.38 | pKi | 4200 | nM | Ki | Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783] |
| GtoPdb | Inhibition of human recombinant cathepsin V. | - | 5.38 | pKi | 4200 | nM | Ki | Bioorg Med Chem (2011) 19: 1477-81 [PMID:21277783] |
| ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem (2011) 19: 1477-1481 [PMID:21277783] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.48 | pIC50 | 33000 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake | F | 4.57 | pIC50 | 27100 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 after 72 hrs by [3H]hypoxanthine uptake | F | 4.69 | pIC50 | 20500 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| ChEMBL | Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.7 | pIC50 | 20100 | nM | IC50 | J Nat Prod (2001) 64: 1221-1223 [PMID:11575960] |
| TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
| GtoPdb | - | - | 4.91 | pIC50 | 12430 | nM | IC50 | Br J Pharmacol (2021) 178: 1669-1683 [PMID:33501656] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
