Citrusinine II [Ligand Id: 11377] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL465847 (Citrusinine-Ii)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911]
ChEMBL Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots B 5.38 pKi 4200 nM Ki Bioorg. Med. Chem. (2011) 19: 1477-1481 [PMID:21277783]
GtoPdb Inhibition of human recombinant cathepsin V. - 5.38 pKi 4200 nM Ki Bioorg Med Chem (2011) 19: 1477-81 [PMID:21277783]
ChEMBL Inhibition of human recombinant cathepsin V expressed in Pichia pastoris B 5 pIC50 10000 nM IC50 Bioorg. Med. Chem. (2011) 19: 1477-1481 [PMID:21277783]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake F 4.48 pIC50 33000 nM IC50 J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake F 4.57 pIC50 27100 nM IC50 J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 after 72 hrs by [3H]hypoxanthine uptake F 4.69 pIC50 20500 nM IC50 J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960]
ChEMBL Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake F 4.7 pIC50 20100 nM IC50 J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]