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ChEMBL ligand: CHEMBL465847 (Citrusinine-Ii) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots | B | 5.38 | pKi | 4200 | nM | Ki | Bioorg. Med. Chem. (2011) 19: 1477-1481 [PMID:21277783] |
GtoPdb | Inhibition of human recombinant cathepsin V. | - | 5.38 | pKi | 4200 | nM | Ki | Bioorg Med Chem (2011) 19: 1477-81 [PMID:21277783] |
ChEMBL | Inhibition of human recombinant cathepsin V expressed in Pichia pastoris | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg. Med. Chem. (2011) 19: 1477-1481 [PMID:21277783] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.48 | pIC50 | 33000 | nM | IC50 | J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960] |
ChEMBL | Antiplasmodial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake | F | 4.57 | pIC50 | 27100 | nM | IC50 | J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 after 72 hrs by [3H]hypoxanthine uptake | F | 4.69 | pIC50 | 20500 | nM | IC50 | J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960] |
ChEMBL | Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | F | 4.7 | pIC50 | 20100 | nM | IC50 | J. Nat. Prod. (2001) 64: 1221-1223 [PMID:11575960] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]