tissue factor pathway inhibitor   Click here for help

GtoPdb Ligand ID: 11181

Comment: TFPI is a serine protease inhibitor that regulates the tissue factor (TF)-dependent blood coagulation pathway (extrinsic pathway). It inhibits activated factor X (Xa) and VIIa-TF proteases in an autoregulatory loop. Some isoforms are tethered to the cell membrane by expression of a glycosylphosphatidylinositol (GPI) anchor, others isoforms are secreted [1-2]. Inhibition of the TFPI restores hemostasis, which is a mechanism being exploited for therapeutic benefit in inherited bleeding disorders.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TFPI tissue factor pathway inhibitor Human pro-TFPI EPI, extrinsic pathway inhibitor
Database Links Click here for help
Ensembl Gene ENSG00000003436 (Hs)
Entrez Gene 7035 (Hs)
GtoPdb PubChem SID 434122241
Human Protein Atlas ENSG00000003436 (Hs)
OMIM 52310 (Hs)
UniProtKB P10646 (Hs)