ChEMBL ligand: CHEMBL1566 (Acarbose, BAY G 5421, BAY-G-5421, Glucobay, NSC-758915, Precose)
alpha glucosidase/Acidic alpha-glucosidase in Rat [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9] There should be some charts here, you may need to enable JavaScript!
Alpha-glucosidase in Geobacillus stearothermophilus [ChEMBL: CHEMBL4412] [UniProtKB: P94451] There should be some charts here, you may need to enable JavaScript!
alpha glucosidase/Lysosomal alpha-glucosidase in Human [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253] alpha glucosidase/Lysosomal alpha-glucosidase in Mouse [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699] There should be some charts here, you may need to enable JavaScript!
Oligo-1,6-glucosidase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5848] [UniProtKB: P53051] There should be some charts here, you may need to enable JavaScript!
Pancreatic alpha-amylase in Pig [ChEMBL: CHEMBL5730] [UniProtKB: P00690] There should be some charts here, you may need to enable JavaScript!
Salivary alpha-amylase in Human [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6] There should be some charts here, you may need to enable JavaScript!
Sucrase-isomaltase in Rat [ChEMBL: CHEMBL3114] [UniProtKB: P23739] There should be some charts here, you may need to enable JavaScript!
amylase alpha 2A in Pig [GtoPdb: 2596] There should be some charts here, you may need to enable JavaScript!
maltase-glucoamylase in Mouse [GtoPdb: 2627] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
ChEMBL	Competitive inhibition of rat alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by HPLC and Michaelis-Menten equation	B	5.46	pKi	3500	nM	Ki	Bioorg. Med. Chem. Lett. (2011) 21: 2441-2444 [PMID:21397496]
ChEMBL	Inhibition of rat intestinal maltase using maltose as substrate by colorimetric analysis	B	4.59	pIC50	25520	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 2022-2026 [PMID:23466232]
ChEMBL	Inhibition of rat intestinal alpha-glucosidase using para-nitrophenyl-alpha-D-glucopyranoside as substrate incubated for 5 min prior to substrate addition measured after 5 min by spectrophotometric analysis	B	4.73	pIC50	18600	nM	IC50	Med Chem Res (2012) 21: 760-774
ChEMBL	Inhibition of maltase in rat intestinal mucosa pre-incubated for 40 mins using maltose substrate	B	4.79	pIC50	16100	nM	IC50	J. Nat. Prod. (2015) 78: 1977-1989 [PMID:26287401]
ChEMBL	Inhibition of rat intestinal alpha-glucosidase using p-nitrophenyl- alpha-D-glucopyranoside as substrate preincubated for 5 min before addition of substrate measured after 10 min	B	5.2	pIC50	6380	nM	IC50	Med Chem Res (2011) 20: 1431-1437
ChEMBL	Inhibition of rat intestinal maltase using maltose as substrate assessed as D-glucose release from substrate preincubated for 15 mins measured after 60 mins	B	5.48	pIC50	3300	nM	IC50	Bioorg. Med. Chem. (2013) 21: 5442-5450 [PMID:23810673]
ChEMBL	Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method	B	5.68	pIC50	2100	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 4529-4533 [PMID:26343830]
ChEMBL	Inhibition of rat intestinal maltase	B	5.7	pIC50	2000	nM	IC50	Bioorg. Med. Chem. (2011) 19: 2015-2022 [PMID:21345683]
ChEMBL	Inhibition of alpha-glucosidase activity of maltase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins	B	5.7	pIC50	2000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 832-840 [PMID:22209731]
ChEMBL	Inhibition of rat small intestinal maltase after 30 mins	B	5.77	pIC50	1700	nM	IC50	Bioorg. Med. Chem. (2011) 19: 2252-2262 [PMID:21420866]
ChEMBL	Inhibition of rat small intestinal maltase after 30 mins by glucose-oxidase method	B	5.77	pIC50	1700	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 3159-3162 [PMID:21454075]
ChEMBL	Inhibition of rat intestinal alpha-glucosidase maltase using maltose as substrate preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry	B	5.82	pIC50	1500	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 1538-1540 [PMID:22290077]
ChEMBL	Inhibition of rat intestine maltase using maltose as substrate incubated for 10 mins prior to substrate addition measured after 40 mins by glucose oxidase colorimetric method	B	5.82	pIC50	1500	nM	IC50	Eur. J. Med. Chem. (2013) 66: 296-304 [PMID:23811091]
ChEMBL	Inhibition of rat intestinal brush border membrane maltase	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL	Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry	B	6.74	pIC50	180	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 3298-3301 [PMID:24973028]
ChEMBL	Inhibition of rat intestinal maltase using moltose as substrate	B	6.74	pIC50	180	nM	IC50	J. Med. Chem. (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Inhibition of Wistar rat small intestine maltase after 30 mins	B	6.8	pIC50	160	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 738-741 [PMID:21185187]
Alpha-glucosidase in Geobacillus stearothermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4412] [UniProtKB: P94451]
ChEMBL	Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by HPLC and Michaelis-Menten equation	B	6.47	pKi	340	nM	Ki	Bioorg. Med. Chem. Lett. (2011) 21: 2441-2444 [PMID:21397496]
alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
ChEMBL	Inhibition of human lysosomal alpha-glucosidase	B	4.38	pIC50	42000	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL	Inhibition of maltase in human Caco-2 cell model system after 2 hrs	B	5.3	pIC50	5000	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
alpha glucosidase/Lysosomal alpha-glucosidase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699]
ChEMBL	Inhibition of liver glucosidase in Swiss mouse liver extracts	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 7011-7014 [PMID:23102653]
Oligo-1,6-glucosidase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5848] [UniProtKB: P53051]
ChEMBL	Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins measured after 30 mins	B	4.42	pIC50	38250	nM	IC50	Bioorg. Med. Chem. (2014) 22: 1195-1200 [PMID:24398385]
Pancreatic alpha-amylase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5730] [UniProtKB: P00690]
ChEMBL	Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method	B	4.45	pIC50	35500	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 7011-7014 [PMID:23102653]
ChEMBL	Inhibition of pig pancreatic alpha-amylase by Bernfeld method	B	4.45	pIC50	35500	nM	IC50	Eur. J. Med. Chem. (2013) 59: 304-309 [PMID:23262035]
Salivary alpha-amylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6]
ChEMBL	Inhibition of human salivary alpha-amylase	B	6	pIC50	996	nM	IC50	J. Med. Chem. (2008) 51: 3555-3561 [PMID:18507367]
ChEMBL	Inhibition of human salivary alpha-amylase using GalG2CNP as substrate by UV-Vis spectrophotometric analysis	B	6.3	pIC50	500	nM	IC50	Bioorg. Med. Chem. (2015) 23: 6725-6732 [PMID:26395057]
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739]
ChEMBL	Inhibition of rat intestinal sucrase using p-nitrophenyl-alpha-d-glucopyranoside as substrate incubated for 10 mins prior to substrate addition measured after 5 mins by spectrophotometry	B	4.3	pIC50	<50000	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 1192-1196 [PMID:24461297]
ChEMBL	Inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by glucose oxidase method	B	4.59	pIC50	26000	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 4529-4533 [PMID:26343830]
ChEMBL	Inhibition of sucrase in rat intestinal mucosa pre-incubated for 40 mins using sucrose substrate	B	4.69	pIC50	20200	nM	IC50	J. Nat. Prod. (2015) 78: 1977-1989 [PMID:26287401]
ChEMBL	Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 3298-3301 [PMID:24973028]
ChEMBL	Inhibition of Wistar rat small intestine sucrase after 30 mins	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 738-741 [PMID:21185187]
ChEMBL	Inhibition of rat intestinal sucrase using sucrose as substrate	B	5.54	pIC50	2900	nM	IC50	J. Med. Chem. (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Inhibition of rat intestinal sucrase using sucrose substrate incubated for 10 mins	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 5530-5533 [PMID:25451999]
ChEMBL	Inhibition of rat intestinal alpha-glucosidase sucrase using sucrose as substrate preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry	B	5.62	pIC50	2380	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 1538-1540 [PMID:22290077]
ChEMBL	Inhibition of sucrase in rat small intestine using sucrose as substrate after 40 mins by microplate reader analysis	B	5.64	pIC50	2300	nM	IC50	MedChemComm (2012) 3: 1466-1470
ChEMBL	Inhibition of rat intestine sucrase using sucrose as substrate incubated for 10 mins prior to substrate addition measured after 40 mins by glucose oxidase colorimetric method	B	5.64	pIC50	2300	nM	IC50	Eur. J. Med. Chem. (2013) 66: 296-304 [PMID:23811091]
ChEMBL	Inhibition of rat small intestinal sucrase after 30 mins	B	5.7	pIC50	2000	nM	IC50	Bioorg. Med. Chem. (2011) 19: 2252-2262 [PMID:21420866]
ChEMBL	Inhibition of rat intestinal sucrase	B	5.77	pIC50	1700	nM	IC50	Bioorg. Med. Chem. (2011) 19: 2015-2022 [PMID:21345683]
ChEMBL	Inhibition of alpha-glucosidase activity of sucrase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins	B	5.77	pIC50	1700	nM	IC50	Bioorg. Med. Chem. (2012) 20: 832-840 [PMID:22209731]
ChEMBL	Inhibition of rat small intestinal sucrase after 30 mins by glucose-oxidase method	B	5.82	pIC50	1500	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 3159-3162 [PMID:21454075]
ChEMBL	Inhibition of rat intestinal brush border membrane sucrase	B	6.25	pIC50	560	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL	Inhibition of rat intestinal sucrase using sucrose as substrate assessed as D-glucose release from substrate preincubated for 15 mins measured after 60 mins	B	6.4	pIC50	400	nM	IC50	Bioorg. Med. Chem. (2013) 21: 5442-5450 [PMID:23810673]
amylase alpha 2A in Pig [GtoPdb: 2596]
GtoPdb	-	-	4.45	pIC50	35500	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7011-4 [PMID:23102653]
maltase-glucoamylase in Mouse [GtoPdb: 2627]
GtoPdb	Affinity measured across splice variants of mouse MGAM catalytic subunit ctMGAM	-	8.05	pKi	9	nM	Ki	Bioorg Med Chem (2011) 19: 3929-34 [PMID:21669536]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]