Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	1857	7q34	MGAM	maltase-glucoamylase
Mouse	-	1827	6 B1	Mgam	maltase-glucoamylase
Rat	-	-	4q22	Mgam	maltase-glucoamylase

Previous and Unofficial Names

maltase-glucoamylase, intestinal | MGA | maltase-glucoamylase (alpha-glucosidase)

Database Links
Alphafold	O43451 (Hs)
BRENDA	3.2.1.20, 3.2.1.3
ChEMBL Target	CHEMBL2074 (Hs)
DrugBank Target	O43451 (Hs)
Ensembl Gene	ENSG00000257335 (Hs), ENSMUSG00000068587 (Mm)
Entrez Gene	8972 (Hs), 232714 (Mm), 312272 (Rn)
Human Protein Atlas	ENSG00000257335 (Hs)
KEGG Enzyme	3.2.1.20, 3.2.1.3
KEGG Gene	hsa:8972 (Hs), mmu:232714 (Mm), rno:312272 (Rn)
OMIM	154360 (Hs)
Pharos	O43451 (Hs)
RefSeq Nucleotide	NM_004668 (Hs), NM_001171003 (Mm)
RefSeq Protein	NP_004659 (Hs), NP_001164474 (Mm)
SynPHARM	79525 (in complex with miglitol)
UniProtKB	O43451 (Hs)
Wikipedia	MGAM (Hs)

Enzyme Reaction
EC Number: 3.2.1.20 EC Number: 3.2.1.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference acarbose Mm Inhibition 7.6 – 8.1 pKi 1 ⤷ pKi 7.6 – 8.1 (Ki 2.8x10-8 – 9x10-9 M) [1] Description: Affinity measured across splice variants of mouse MGAM catalytic subunit ctMGAM miglitol Mm Inhibition 6.0 – 6.7 pKi 1 ⤷ pKi 6.0 – 6.7 (Ki 1x10-6 – 2.11x10-7 M) Inhibition across MGAM catalytic subunits [1] miglitol Hs Inhibition 6.0 pKi 2 ⤷ pKi 6.0 (Ki 1x10-6 M) [2] Description: Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay
View species-specific inhibitor tables
Inhibitor Comments
Miglitol may also inhibit the lysosomal alpha-glucosidase (GAA) enzyme. Human maltase-glucoamylase is likely to be the primary molecular target of acarbose.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cellular signalling