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ChEMBL ligand: CHEMBL399379 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085] | ||||||||
ChEMBL | Inhibition of human ACC1 | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874] |
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763] | ||||||||
ChEMBL | Inhibition of human ACC2 | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874] |
ATP citrate lyase/ATP-citrate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3720] [GtoPdb: 3245] [UniProtKB: P53396] | ||||||||
ChEMBL | Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay | B | 6.35 | pIC50 | 442 | nM | IC50 | Eur J Med Chem (2017) 126: 920-928 [PMID:27997879] |
ChEMBL | Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay | B | 6.42 | pIC50 | 377 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 929-935 [PMID:28129980] |
ChEMBL | Inhibition of human recombinant ATP-citrate lyase | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874] |
GtoPdb | - | - | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3208-11 [PMID:17383874] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]