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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 2458 | 12q24.11 | ACACB | acetyl-CoA carboxylase beta | |
| Mouse | - | - | Acacb | acetyl-Coenzyme A carboxylase beta | ||
| Rat | - | - | Acacb | acetyl-CoA carboxylase beta | ||
| Previous and Unofficial Names |
| ACACB | ACCβ | ACCB | acetyl-Coenzyme A carboxylase beta | acetyl-CoA carboxylase beta | acetyl-Coenzyme A carboxylase 2 |
| Database Links |
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| Alphafold | O00763 (Hs) |
| BRENDA | 6.4.1.2 |
| CATH/Gene3D | 3.30.1490.20 |
| ChEMBL Target | CHEMBL4829 (Hs) |
| Ensembl Gene | ENSG00000076555 (Hs), ENSMUSG00000042010 (Mm), ENSRNOG00000000658 (Rn) |
| Entrez Gene | 32 (Hs), 100705 (Mm), 116719 (Rn) |
| Human Protein Atlas | ENSG00000076555 (Hs) |
| KEGG Enzyme | 6.4.1.2 |
| KEGG Gene | hsa:32 (Hs), mmu:100705 (Mm), rno:116719 (Rn) |
| OMIM | 601557 (Hs) |
| Pharos | O00763 (Hs) |
| UniProtKB | O00763 (Hs) |
| Wikipedia | ACACB (Hs) |
| Enzyme Reaction |
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| Products |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific inhibitor tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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1. Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. (2009) (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett, 19 (23): 6645-8. [PMID:19853443]
2. Clark RF, Zhang T, Xin Z, Liu G, Wang Y, Hansen TM, Wang X, Wang R, Zhang X, Frevert EU et al.. (2006) Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity. Bioorg Med Chem Lett, 16 (23): 6078-81. [PMID:16973360]
3. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J Med Chem, 56 (17): 7110-9. [PMID:23981033]
4. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci USA, 113 (13): E1796-805. [PMID:26976583]
5. Huard K, Smith AC, Cappon G, Dow RL, Edmonds DJ, El-Kattan A, Esler WP, Fernando DP, Griffith DA, Kalgutkar AS et al.. (2020) Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. J Med Chem, 63 (19): 10879-10896. [PMID:32809824]
6. Takagi H, Tanimoto K, Shimazaki A, Tonomura Y, Momosaki S, Sakamoto S, Abe K, Notoya M, Yukioka H. (2020) A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J Pharmacol Exp Ther, 372 (3): 256-263. [PMID:31900320]
7. Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A et al.. (2008) Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther, 324 (2): 507-16. [PMID:18025247]
8. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res, 63 (21): 7330-7. [PMID:14612531]
Carboxylases: Acetyl-CoA carboxylase 2. Last modified on 09/11/2022. Accessed on 22/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264.
