Acetyl-CoA carboxylase 2 | Carboxylases | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Acetyl-CoA carboxylase 2

Target not currently curated in GtoImmuPdb

Target id: 1264

Nomenclature: Acetyl-CoA carboxylase 2

Abbreviated Name: ACC2

Family: Carboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ACACB acetyl-CoA carboxylase beta
Mouse - - Acacb acetyl-Coenzyme A carboxylase beta
Rat - - Acacb acetyl-CoA carboxylase beta
Previous and Unofficial Names
ACACB | ACCβ | ACCB | acetyl-Coenzyme A carboxylase beta | acetyl-CoA carboxylase beta | acetyl-Coenzyme A carboxylase 2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2e [PMID: 31900320] Hs Inhibition 8.7 pIC50 3
pIC50 8.7 (IC50 1.9x10-9 M) [3]
compound 21 [PMID: 23981033] Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) [1]
A-908292 Hs Inhibition 7.6 pIC50 4
pIC50 7.6 (IC50 2.3x10-8 M) [4]
TOFA Hs Inhibition 4.9 pIC50 5
pIC50 4.9 (IC50 1.23x10-5 M) [5]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Hs Negative 8.2 pIC50 2
pIC50 8.2 (IC50 6.1x10-9 M) [2]


Show »

1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]

2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]

3. Takagi H, Tanimoto K, Shimazaki A, Tonomura Y, Momosaki S, Sakamoto S, Abe K, Notoya M, Yukioka H. (2020) A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J. Pharmacol. Exp. Ther., 372 (3): 256-263. [PMID:31900320]

4. Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A et al.. (2008) Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J. Pharmacol. Exp. Ther., 324 (2): 507-16. [PMID:18025247]

5. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 2. Last modified on 14/02/2020. Accessed on 10/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY,