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Acetyl-CoA carboxylase 2

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Target not currently curated in GtoImmuPdb

Target id: 1264

Nomenclature: Acetyl-CoA carboxylase 2

Abbreviated Name: ACC2

Family: Carboxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ACACB acetyl-CoA carboxylase beta
Mouse - - Acacb acetyl-Coenzyme A carboxylase beta
Rat - - Acacb acetyl-CoA carboxylase beta
Previous and Unofficial Names Click here for help
ACACB | ACCβ | ACCB | acetyl-Coenzyme A carboxylase beta | acetyl-CoA carboxylase beta | acetyl-Coenzyme A carboxylase 2
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 6.4.1.2
Products Click here for help
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2e [PMID: 31900320] Small molecule or natural product Hs Inhibition 8.7 pIC50 3
pIC50 8.7 (IC50 1.9x10-9 M) [3]
compound 21 [PMID: 23981033] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) [1]
A-908292 Small molecule or natural product Hs Inhibition 7.6 pIC50 4
pIC50 7.6 (IC50 2.3x10-8 M) [4]
TOFA Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.9 pIC50 5
pIC50 4.9 (IC50 1.23x10-5 M) [5]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Small molecule or natural product Click here for species-specific activity table Hs Negative 8.2 pIC50 2
pIC50 8.2 (IC50 6.1x10-9 M) [2]

References

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1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]

2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]

3. Takagi H, Tanimoto K, Shimazaki A, Tonomura Y, Momosaki S, Sakamoto S, Abe K, Notoya M, Yukioka H. (2020) A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J. Pharmacol. Exp. Ther., 372 (3): 256-263. [PMID:31900320]

4. Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A et al.. (2008) Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J. Pharmacol. Exp. Ther., 324 (2): 507-16. [PMID:18025247]

5. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 2. Last modified on 14/02/2020. Accessed on 24/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264.