Acetyl-CoA carboxylase 2 | Carboxylases | IUPHAR/BPS Guide to PHARMACOLOGY

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Acetyl-CoA carboxylase 2

Target not currently curated in GtoImmuPdb

Target id: 1264

Nomenclature: Acetyl-CoA carboxylase 2

Abbreviated Name: ACC2

Family: Carboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Contents:

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ACACB acetyl-CoA carboxylase beta
Mouse - - Acacb acetyl-Coenzyme A carboxylase beta
Rat - - Acacb acetyl-CoA carboxylase beta
Previous and Unofficial Names
ACACB | ACCβ | ACCB | acetyl-Coenzyme A carboxylase beta | acetyl-CoA carboxylase beta | acetyl-Coenzyme A carboxylase 2
Database Links
BRENDA 6.4.1.2
CATH/Gene3D 3.30.1490.20
ChEMBL Target CHEMBL4829 (Hs)
Ensembl Gene ENSG00000076555 (Hs), ENSMUSG00000042010 (Mm), ENSRNOG00000000658 (Rn)
Entrez Gene 32 (Hs), 100705 (Mm), 116719 (Rn)
Human Protein Atlas ENSG00000076555 (Hs)
KEGG Enzyme 6.4.1.2
KEGG Gene hsa:32 (Hs), mmu:100705 (Mm), rno:116719 (Rn)
OMIM 601557 (Hs)
Pharos O00763 (Hs)
UniProtKB O00763 (Hs)
Wikipedia ACACB (Hs)
Enzyme Reaction
EC Number: 6.4.1.2
Products
Product Species Reference
Pi Human

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2e [PMID: 31900320] Hs Inhibition 8.7 pIC50 3
⤷ pIC50 8.7 (IC50 1.9x10-9 M) [3]
compound 21 [PMID: 23981033] Hs Inhibition 8.4 pIC50 1
⤷ pIC50 8.4 (IC50 4x10-9 M) [1]
A-908292 Hs Inhibition 7.6 pIC50 4
⤷ pIC50 7.6 (IC50 2.3x10-8 M) [4]
TOFA Hs Inhibition 4.9 pIC50 5
⤷ pIC50 4.9 (IC50 1.23x10-5 M) [5]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
firsocostat Hs Negative 8.2 pIC50 2
⤷ pIC50 8.2 (IC50 6.1x10-9 M) [2]

References

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1. Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W et al.. (2013) Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. J. Med. Chem., 56 (17): 7110-9. [PMID:23981033]

2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R et al.. (2016) Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. U.S.A., 113 (13): E1796-805. [PMID:26976583]

3. Takagi H, Tanimoto K, Shimazaki A, Tonomura Y, Momosaki S, Sakamoto S, Abe K, Notoya M, Yukioka H. (2020) A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J. Pharmacol. Exp. Ther., 372 (3): 256-263. [PMID:31900320]

4. Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A et al.. (2008) Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J. Pharmacol. Exp. Ther., 324 (2): 507-16. [PMID:18025247]

5. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res., 63 (21): 7330-7. [PMID:14612531]

How to cite this page

Carboxylases: Acetyl-CoA carboxylase 2. Last modified on 14/02/2020. Accessed on 10/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264.