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Carboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The carboxylases allow the production of new carbon-carbon bonds by introducing HCO3- or CO2 into target molecules. Two groups of carboxylase activities, some of which are bidirectional, can be defined on the basis of the cofactor requirement, making use of biotin (EC 6.4.1.-) or vitamin K hydroquinone (EC 4.1.1.-).

Enzymes

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Complexes

PCCA,PCCB (Propionyl-CoA carboxylase ) C Show summary »

Enzymes and Subunits

PC (Pyruvate carboxylase) C Show summary »

ACC1 (Acetyl-CoA carboxylase 1) C Show summary » More detailed page go icon to follow link

ACC2 (Acetyl-CoA carboxylase 2) C Show summary » More detailed page go icon to follow link

PCCA (Propionyl-CoA carboxylase α subunit) Show summary »

PCCB (Propionyl-CoA carboxylase β subunit) Show summary »

GGCX (γ-Glutamyl carboxylase) C Show summary » More detailed page go icon to follow link

Comments

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References

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How to cite this family page

Database page citation:

Carboxylases. Accessed on 01/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=255.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.