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ChEMBL ligand: CHEMBL1270230 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of ALK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
GtoPdb | - | - | 6.4 | pIC50 | 394 | nM | IC50 | J Med Chem (2010) 53: 7296-315 [PMID:20873740] |
ChEMBL | Inhibition of Cdk9/cyclin T | B | 6.4 | pIC50 | 394 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of Cdc7 | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2010) 53: 7296-315 [PMID:20873740] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
ChEMBL | Inhibition of Cdk1/cyclin B | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of Cdk2/cyclin A | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
ChEMBL | Inhibition of Cdk2/cyclin E | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
ChEMBL | Inhibition of Cdk4/cyclin D1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of Cdk5/P25 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
ChEMBL | Inhibition of MPS1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
eukaryotic translation initiation factor 2 alpha kinase 3/Eukaryotic translation initiation factor 2-alpha kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6030] [GtoPdb: 2017] [UniProtKB: Q9NZJ5] | ||||||||
ChEMBL | Inhibition of PERK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibition of FAK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 5.86 | pIC50 | 1390 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of MET | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK2 | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of IGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of P38alpha | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Inhibition of P38beta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TRKA | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of PKCbeta | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of AUR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of AUR2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418] | ||||||||
ChEMBL | Inhibition of EEF2K | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
ChEMBL | Inhibition of MST4 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
ChEMBL | Inhibition of NEK6 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
ChEMBL | Inhibition of NIM1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of PIM1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of PLK1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
ChEMBL | Inhibition of TAO1 | B | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
GtoPdb | - | - | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2010) 53: 7296-315 [PMID:20873740] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of KIT | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of ABL | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
ChEMBL | Inhibition of BRK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
ChEMBL | Inhibition of recombinant human JAK2 (808-1132 residues) using LPLDKDYYVVREPGQ as substrate by radiometric assay in presence of [33P]-gamma-ATP | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2014) 22: 4998-5012 [PMID:25009002] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Inhibition of FLT3 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Inhibition of RET | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of SYK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of VEGFR3 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]