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ChEMBL ligand: CHEMBL1270230 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of ALK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
GtoPdb | - | - | 6.4 | pIC50 | 394 | nM | IC50 | J Med Chem (2010) 53: 7296-315 [PMID:20873740] |
ChEMBL | Inhibition of Cdk9/cyclin T | B | 6.4 | pIC50 | 394 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of Cdc7 | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2010) 53: 7296-315 [PMID:20873740] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
ChEMBL | Inhibition of Cdk1/cyclin B | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of Cdk2/cyclin A | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
ChEMBL | Inhibition of Cdk2/cyclin E | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
ChEMBL | Inhibition of Cdk4/cyclin D1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of Cdk5/P25 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
ChEMBL | Inhibition of MPS1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
eukaryotic translation initiation factor 2 alpha kinase 3/Eukaryotic translation initiation factor 2-alpha kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6030] [GtoPdb: 2017] [UniProtKB: Q9NZJ5] | ||||||||
ChEMBL | Inhibition of PERK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibition of FAK | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 5.86 | pIC50 | 1390 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of MET | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK2 | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of IGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MK2 | B | 5 |