Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	313	9q33.3	NEK6	NIMA related kinase 6
Mouse	-	313	2 24.41 cM	Nek6	NIMA (never in mitosis gene a)-related expressed kinase 6
Rat	-	313	3q12	Nek6	NIMA-related kinase 6

Previous and Unofficial Names

NIMA-related kinase 6

Database Links
Alphafold	Q9HC98 (Hs), Q9ES70 (Mm), P59895 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL4309 (Hs)
Ensembl Gene	ENSG00000119408 (Hs), ENSMUSG00000026749 (Mm), ENSRNOG00000010897 (Rn)
Entrez Gene	10783 (Hs), 59126 (Mm), 360161 (Rn)
Human Protein Atlas	ENSG00000119408 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:10783 (Hs), mmu:59126 (Mm), rno:360161 (Rn)
OMIM	604884 (Hs)
Pharos	Q9HC98 (Hs)
RefSeq Nucleotide	NM_001145001 (Hs), NM_001159631 (Mm), NM_182953 (Rn)
RefSeq Protein	NP_001138473 (Hs), NP_001153103 (Mm), NP_891998 (Rn)
UniProtKB	Q9HC98 (Hs), Q9ES70 (Mm), P59895 (Rn)
Wikipedia	NEK6 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 22 [PMID: 20462760] Hs Inhibition - - 5 ⤷ [5] Description: Measured as % inhibition using 3μM compound.
Inhibitor Comments
3μM compound 22 [PMID 20462760] abolishes NEK6 activity [5].

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: NEK6
Ligand Sp. Type Action Value Parameter tamatinib Hs Inhibitor Inhibition 8.2 pKd KW-2449 Hs Inhibitor Inhibition 6.9 pKd fedratinib Hs Inhibitor Inhibition 6.9 pKd SU-14813 Hs Inhibitor Inhibition 6.2 pKd NVP-TAE684 Hs Inhibitor Inhibition 5.9 pKd dovitinib Hs Inhibitor Inhibition 5.8 pKd AST-487 Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: NEK6/NEK6
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM Cdk1/2 inhibitor III Hs Inhibitor Inhibition 78.8 89.0 44.0 JAK inhibitor I Hs Inhibitor Inhibition 82.5 85.0 103.0 tofacitinib Hs Inhibitor Inhibition 83.2 dovitinib Hs Inhibitor Inhibition 84.5 bosutinib Hs Inhibitor Inhibition 85.3 dasatinib Hs Inhibitor Inhibition 86.2 tandutinib Hs Inhibitor Inhibition 87.4 fascaplysin Hs Inhibitor Inhibition 87.8 109.0 104.0 staurosporine Hs Inhibitor Inhibition 88.6 92.0 88.0 isogranulatimide Hs Inhibitor Inhibition 88.7 98.0 90.0
Displaying the top 10 most potent ligands  View all ligands in screen »