serine/threonine-protein kinase MST4 | YSK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine-protein kinase MST4

Target not currently curated in GtoImmuPdb

Target id: 2287

Nomenclature: serine/threonine-protein kinase MST4

Abbreviated Name: MST4

Family: YSK subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 Xq26.2 MST4 serine/threonine-protein kinase MST4
Mouse - 416 X A3.3 Stk26 serine/threonine kinase 26
Rat - 416 Xq36 Stk26 serine/threonine kinase 26
Previous and Unofficial Names
Mst3 and SOK1-related kinase | serine/threonine-protein kinase MASK | mammalian STE20-like protein kinase 4 | 2610018G03Rik | RIKEN cDNA 2610018G03 gene | Mst4 | serine/threonine protein kinase MST4 | serine/threonine protein kinase 26
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2-3

Key to terms and symbols Click column headers to sort
Target used in screen: MST4
Ligand Sp. Type Action Value Parameter
neratinib Hs Inhibitor Inhibition 8.1 pKd
bosutinib Hs Inhibitor Inhibition 7.4 pKd
staurosporine Hs Inhibitor Inhibition 6.8 pKd
lestaurtinib Hs Inhibitor Inhibition 6.6 pKd
SU-14813 Hs Inhibitor Inhibition 6.5 pKd
sunitinib Hs Inhibitor Inhibition 6.5 pKd
NVP-TAE684 Hs Inhibitor Inhibition 6.3 pKd
dovitinib Hs Inhibitor Inhibition 6.3 pKd
KW-2449 Hs Inhibitor Inhibition 6.0 pKd
JNJ-28312141 Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/MSTR4
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Hs Inhibitor Inhibition 4.4
Cdk1/2 inhibitor III Hs Inhibitor Inhibition 4.5
bosutinib Hs Inhibitor Inhibition 5.9
PKR inhibitor Hs Inhibitor Inhibition 10.8
SB 218078 Hs Inhibitor Inhibition 20.5
PKCbeta inhibitor Hs Inhibitor Inhibition 22.2
midostaurin Hs Inhibitor Inhibition 23.8
JAK3 inhibitor VI Hs Inhibitor Inhibition 27.3
GF109203X Hs Inhibitor Inhibition 37.2
Gö 6983 Hs Inhibitor Inhibition 40.4
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YSK subfamily: serine/threonine-protein kinase MST4. Last modified on 01/08/2014. Accessed on 08/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2287.