GF109203X

Ligand id: 5193

Name: GF109203X

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 70.13
Molecular weight 412.19
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Classification
Compound class Synthetic organic
IUPAC Name
3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Synonyms
bisindolylmaleimide I | Gö6850 | GF 109203X
Comments
GF109203X is a potent, ATP-competitive PKC inhibitor [3].
Database Links
CAS Registry No. 133052-90-1
ChEMBL Ligand CHEMBL7463
GtoPdb PubChem SID 178101881
PubChem CID 2396
RCSB PDB Ligand BI1
Search Google for chemical match using the InChIKey QMGUOJYZJKLOLH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QMGUOJYZJKLOLH
Search UniChem for chemical match using the InChIKey QMGUOJYZJKLOLH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QMGUOJYZJKLOLH
Wikipedia BIM-1

Product suppliers

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Tocris
GF 109203X
Cat. No. 0741