henatinib [Ligand Id: 9930] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1277072 (Henatinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of human PDGFRbeta after 30 mins by ELISA | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2010) 53: 8140-8149 [PMID:21028894] |
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2010) 53: 8140-9 [PMID:21028894] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of c-Kit after 30 mins by ELISA | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2010) 53: 8140-8149 [PMID:21028894] |
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2010) 53: 8140-9 [PMID:21028894] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of human VEGFR2 after 30 mins by ELISA | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2010) 53: 8140-8149 [PMID:21028894] |
| GtoPdb | - | - | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2010) 53: 8140-9 [PMID:21028894] |
| ChEMBL | Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B method | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2010) 53: 8140-8149 [PMID:21028894] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
