leflunomide   Click here for help

GtoPdb Ligand ID: 6825

Synonyms: Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Approved drug Immunopharmacology Ligand
leflunomide is an approved drug (FDA (1998), EMA (1999))
Compound class: Synthetic organic
Comment: Inhibits dihydroorotate dehydrogenase.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.13
Molecular weight 270.06
XLogP 2.79
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
Isomeric SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
InChI InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChI Key VHOGYURTWQBHIL-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1998), EMA (1999))
Is prodrug? Yes
Active form teriflunomide
IUPAC Name Click here for help
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
International Nonproprietary Names Click here for help
INN number INN
5079 leflunomide
Synonyms Click here for help
Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Database Links Click here for help
CAS Registry No. 75706-12-6
ChEMBL Ligand CHEMBL960
DrugBank Ligand DB01097
DrugCentral Ligand 1552
GtoPdb PubChem SID 178103431
PubChem CID 3899
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Wikipedia Leflunomide

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Tocris
Leflunomide
Cat. No. 2228