leflunomide   Click here for help

GtoPdb Ligand ID: 6825

Synonyms: Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Approved drug Immunopharmacology Ligand
leflunomide is an approved drug (FDA (1998), EMA (1999))
Compound class: Synthetic organic
Comment: Inhibits dihydroorotate dehydrogenase.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.13
Molecular weight 270.06
XLogP 2.79
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
Isomeric SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
InChI InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1998), EMA (1999))
Is prodrug? Yes
Active form teriflunomide
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
5079 leflunomide
Synonyms Click here for help
Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Database Links Click here for help
CAS Registry No. 75706-12-6
DrugBank Ligand DB01097
DrugCentral Ligand 1552
GtoPdb PubChem SID 178103431
PubChem CID 3899
Search Google for chemical match using the InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N
Wikipedia Leflunomide

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Leflunomide (links to external site)
Cat. No. 2228