Synonyms: Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
leflunomide is an approved drug (FDA (1998), EMA (1999))
Compound class:
Synthetic organic
Comment: Inhibits dihydroorotate dehydrogenase.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
Leflunomide acts as a pyrimidine synthesis inhibitor. It is rapidly and almost completely metabolized following oral administration to its pharmacologically active metabolite, A77 1726. Its mechanism of action has not been fully resolved but appears to be associated with a reduction in the pyrimidine level, which in turn has an inhibitory effect on autoimmune T cells [1]. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA) |