leflunomide   Click here for help

GtoPdb Ligand ID: 6825

Synonyms: Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Approved drug Immunopharmacology Ligand
leflunomide is an approved drug (FDA (1998), EMA (1999))
Compound class: Synthetic organic
Comment: Inhibits dihydroorotate dehydrogenase.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.13
Molecular weight 270.06
XLogP 2.79
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
Isomeric SMILES O=C(c1cnoc1C)Nc1ccc(cc1)C(F)(F)F
InChI InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChI Key VHOGYURTWQBHIL-UHFFFAOYSA-N
Immunopharmacology Comments
Leflunomide acts as a disease modifying anti-rheumatic drug (DMARD).
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
A DMARD approved for active RA.