saclofen [Ligand Id: 1078] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL312403 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GABAB2/GABAB1/GABA-B receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111463] [GtoPdb: 241, 240] [UniProtKB: O75899, Q9UBS5] | ||||||||
| ChEMBL | Inhibition of Gamma-aminobutyric acid type B receptor | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 237-240 |
| ChEMBL | Inhibition of Gamma-aminobutyric acid type B receptor | B | 4.48 | pIC50 | 33000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 237-240 |
| GABAB2/GABAB1 in Rat [GtoPdb: 241, 240] [UniProtKB: O88871, Q9Z0U4] | ||||||||
| GtoPdb | - | - | 3.5 | pIC50 | - | - | - | Nature (1997) 386: 239-46 [PMID:9069281] |
| GABAB receptor in Human [GtoPdb: 242] | ||||||||
| GtoPdb | - | - | 4.3 | pKi | - | - | - |
Br J Pharmacol (2000) 131: 1050-4 [PMID:11082110]; Biochem Pharmacol (2003) 65: 1103-13 [PMID:12663046] |
| GABAB receptor in Rat [GtoPdb: 242] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | Pharmacol Rev (2002) 54: 247-64 [PMID:12037141] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
