ifosfamide

Ligand id: 7201

Name: ifosfamide

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 51.38
Molecular weight 260.02
XLogP 0.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1988))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one
International Nonproprietary Names
INN number INN
2865 ifosfamide
Synonyms
Holoxan® | Ifex® | MJF-9325 | Z-4942
Comments
Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) [1].
Database Links
CAS Registry No. 3778-73-2
ChEMBL Ligand CHEMBL1024
DrugBank Ligand DB01181
GtoPdb PubChem SID 178103776
PubChem CID 3690
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Wikipedia Ifosfamide