- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: Holoxan® | Ifex® | MJF-9325 | Z-4942
ifosfamide is an approved drug (FDA (1988))
Compound class: Synthetic organic
Comment: Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) .
View more information in the IUPHAR Pharmacology Education Project: ifosfamide
1. Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L, Lorente G, Banica M, Jung D, Wang J et al.. (2008)
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
J Med Chem, 51 (8): 2412-20. [PMID:18257544]