A778317 [Ligand Id: 4120] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628687 (A-778317)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Displacement of [3H]A-778317 from human TRPV1 expressed in CHO cell membranes after 60 mins by scintillation counting method B 8.47 pKd 3.4 nM Kd J Med Chem (2017) 60: 8246-8252 [PMID:28892388]
GtoPdb - - 8.3 pIC50 5 nM IC50 J. Pharmacol. Exp. Ther. (2007) 323: 285-93 [PMID:17660385]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]