taprenepag [Ligand Id: 5816] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2107783 (Taprenepag) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Binding affinity to EP1 receptor (unknown origin) | B | 5.49 | pKi | >3200 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| GtoPdb | - | - | 8 | pIC50 | - | - | - | Exp Eye Res (2011) 93: 256-64 [PMID:21376717] |
| ChEMBL | Agonist activity at EP2 receptor (unknown origin) by functional assay | B | 8.55 | pEC50 | 2.8 | nM | EC50 | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | - | - | - | Exp Eye Res (2011) 93: 256-64 [PMID:21376717] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Binding affinity to EP3 receptor (unknown origin) | B | 5.49 | pKi | >3200 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Binding affinity to EP4 receptor (unknown origin) | B | 5.49 | pKi | >3200 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
