taprenepag [Ligand Id: 5816] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2107783 (Taprenepag)
  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
There should be some charts here, you may need to enable JavaScript!
  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
There should be some charts here, you may need to enable JavaScript!
  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
There should be some charts here, you may need to enable JavaScript!
  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Binding affinity to EP1 receptor (unknown origin) B 5.49 pKi >3200 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Binding affinity to EP2 receptor (unknown origin) by competitive binding assay B 8 pKi 10 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb - - 8 pIC50 - - - Exp Eye Res (2011) 93: 256-64 [PMID:21376717]
ChEMBL Agonist activity at EP2 receptor (unknown origin) by functional assay B 8.55 pEC50 2.8 nM EC50 J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 8.3 pIC50 - - - Exp Eye Res (2011) 93: 256-64 [PMID:21376717]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Binding affinity to EP3 receptor (unknown origin) B 5.49 pKi >3200 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Binding affinity to EP4 receptor (unknown origin) B 5.49 pKi >3200 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]