albiglutide

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Ligands
albiglutide

Ligand id: 7386

Name: albiglutide

Classification
Compound class	Peptide or derivative
Approved drug?	Yes (FDA and EMA (2014))

International Nonproprietary Names
INN number	INN
8829	albiglutide

Synonyms
Eperzan® \| GSK716155 \| Tanzeum®

Synonyms

Eperzan® | GSK716155 | Tanzeum®

Comments
Albiglutide is recombinant protein engineered by fusing the gene for glucagon-like peptide 1 (GLP-1; an incretin secreted in the gut) with the gene for human albumin. In this case the GLP-1 appears to contain an amino acid substitution (Ala to Glu at the C-terminal) directly adjacent to the dipeptidyl peptidase-4 (DPP-4; the enzyme responsible for in vivo degradation of GLP-1) hydrolysis site, which renders the peptide resistant to cleavage by this enzyme [3,5]. In conjunction with the fusion to albumin [2] this drug has an extended half-life compared to other approved drug GLP-1 mimetics.

Comments

Albiglutide is recombinant protein engineered by fusing the gene for glucagon-like peptide 1 (GLP-1; an incretin secreted in the gut) with the gene for human albumin. In this case the GLP-1 appears to contain an amino acid substitution (Ala to Glu at the C-terminal) directly adjacent to the dipeptidyl peptidase-4 (DPP-4; the enzyme responsible for in vivo degradation of GLP-1) hydrolysis site, which renders the peptide resistant to cleavage by this enzyme [3,5]. In conjunction with the fusion to albumin [2] this drug has an extended half-life compared to other approved drug GLP-1 mimetics.

Database Links
Specialist databases
IMGT/mAb-DB	397
Other databases
ChEMBL Ligand	CHEMBL2107841
GtoPdb PubChem SID	178103958
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Wikipedia	Albiglutide