albiglutide   Click here for help

GtoPdb Ligand ID: 7386

Synonyms: Eperzan® | GSK716155 | Tanzeum®
Approved drug
albiglutide is an approved drug (FDA and EMA (2014))
Comment: Albiglutide is recombinant protein engineered by fusing the gene for glucagon-like peptide 1 (GLP-1; an incretin secreted in the gut) with the gene for human albumin. In this case the GLP-1 appears to contain an amino acid substitution (Ala to Glu at the C-terminal) directly adjacent to the dipeptidyl peptidase-4 (DPP-4; the enzyme responsible for in vivo degradation of GLP-1) hydrolysis site, which renders the peptide resistant to cleavage by this enzyme [3,5]. In conjunction with the fusion to albumin [2] this drug has an extended half-life compared to other approved drug GLP-1 mimetics.
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Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2014))
International Nonproprietary Names Click here for help
INN number INN
8829 albiglutide
Synonyms Click here for help
Eperzan® | GSK716155 | Tanzeum®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 397
Other databases
ChEMBL Ligand CHEMBL2107841
GtoPdb PubChem SID 178103958
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Wikipedia Albiglutide