roxindole [Ligand Id: 52] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL431367 (Roxindole)
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
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  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand B 5 pKi >10000 nM Ki J Med Chem (1996) 39: 3179-3187 [PMID:8759640]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Compound was evaluated for effective concentration in vivo for Dopamine receptor D2 mitogenesis. (95% confidence intervals) F 9.43 pEC50 0.37 nM EC50 J Med Chem (1996) 39: 3179-3187 [PMID:8759640]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL In vitro binding affinity for dopamine receptor D2 on rat striatal membranes by [3H]spiperone displacement. B 7.85 pKi 14 nM Ki J Med Chem (1997) 40: 250-259 [PMID:9003524]
ChEMBL Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]spiperone displacement. B 8.04 pKi 9.1 nM Ki J Med Chem (1996) 39: 3179-3187 [PMID:8759640]
ChEMBL Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes [3H]ADTN, a dopamine agonist F 9.06 pKi 0.88 nM Ki J Med Chem (1992) 35: 4020-4026 [PMID:1359142]
ChEMBL Compound was evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes 3[H]spiperone, a dopamine antagonist F 8.23 pIC50 5.95 nM IC50 J Med Chem (1992) 35: 4020-4026 [PMID:1359142]
ChEMBL Displacement of [3H]spiperone from dopamine D2 receptor of rat striatal membranes B 8.25 pIC50 5.6 nM IC50 J Med Chem (2004) 47: 4677-4683 [PMID:15341483]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 8.9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]spiperone as radioligand B 9.4 pKi 0.4 nM Ki J Med Chem (1996) 39: 3179-3187 [PMID:8759640]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity against human Dopamine receptor D4 in CHO-K1 cells using [3H]spiperone as radioligand B 7.62 pKi 24 nM Ki J Med Chem (1996) 39: 3179-3187 [PMID:8759640]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 9.9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
ChEMBL Inhibition of 5HT1A receptor B 9.1 pIC50 0.8 nM IC50 Bioorg Med Chem Lett (2010) 20: 1118-1123 [PMID:20022748]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells B 9.1 pIC50 0.8 nM IC50 J Med Chem (2004) 47: 4677-4683 [PMID:15341483]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 6 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 7.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 447-53 [PMID:10431754];
J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 7.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 6.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 8.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 8.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 8.8 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]