5-HT<sub>1D</sub> receptor | 5-Hydroxytryptamine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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5-HT1D receptor

Target not currently curated in GtoImmuPdb

Target id: 3

Nomenclature: 5-HT1D receptor

Family: 5-Hydroxytryptamine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 377 1p36.3-p34.3 HTR1D 5-hydroxytryptamine receptor 1D 49
Mouse 7 374 4 D3 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 50
Rat 7 374 5q36 Htr1d 5-hydroxytryptamine receptor 1D 11
Previous and Unofficial Names
5-HT1Dα [49] | HTRL | 5-HT1D | HT1DA | serotonin receptor 1D | Gpcr14 | Htr1db | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Database Links
Specialist databases
GPCRDB 5ht1d_human (Hs), 5ht1d_mouse (Mm), 5ht1d_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
5-HT-moduline
5-hydroxytryptamine

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]eletriptan Hs Full agonist 9.1 pKd 29
pKd 9.1 (Kd 9x10-10 M) [29]
[3H]5-CT Hs Agonist 9.1 pKd 53
pKd 9.1 (Kd 9x10-10 M) [53]
[3H]8-OH-DPAT Hs Full agonist 9.0 pKd 30
pKd 9.0 (Kd 1x10-9 M) [30]
[125I]GTI Rn Agonist 8.9 pKd 3-4
pKd 8.9 (Kd 1.3x10-9 M) [3-4]
[3H]alniditan Hs Full agonist 8.9 – 8.9 pKd 19
pKd 8.9 – 8.9 (Kd 1.4x10-9 – 1.2x10-9 M) [19]
[3H]5-HT Hs Full agonist 8.2 – 8.6 pKd 19,43,49
pKd 8.2 – 8.6 [19,43,49]
[3H]sumatriptan Hs Full agonist 8.2 pKd 29
pKd 8.2 (Kd 7x10-9 M) [29]
donitriptan Rn Full agonist 9.6 pKi 15
pKi 9.6 [15]
dihydroergotamine Hs Full agonist 9.2 – 9.9 pKi 12,19-20
pKi 9.2 – 9.9 [12,19-20]
oxymetazoline Hs Partial agonist 9.4 pKi 18
pKi 9.4 [18]
donitriptan Hs Full agonist 9.3 pKi 15
pKi 9.3 [15]
7-methoxy-1-naphthylpiperazine Hs Full agonist 9.2 pKi 16
pKi 9.2 [16]
lysergol Hs Full agonist 9.2 pKi 49
pKi 9.2 [49]
ergotamine Hs Agonist 9.1 pKi 10
pKi 9.1 (Ki 8x10-10 M) [10]
PNU109291 Gg Agonist 9.1 pKi 8
pKi 9.1 (Ki 9x10-10 M) [8]
alniditan Hs Full agonist 8.7 – 9.4 pKi 19-20
pKi 8.7 – 9.4 [19-20]
L-694,247 Hs Agonist 9.0 pKi 52
pKi 9.0 (Ki 1x10-9 M) [52]
lisuride Hs Partial agonist 9.0 pKi 24
pKi 9.0 [24]
ziprasidone Hs Full agonist 9.0 pKi 42
pKi 9.0 [42]
5-CT Hs Full agonist 8.6 – 9.2 pKi 12,20,49
pKi 8.6 – 9.2 [12,20,49]
eletriptan Hs Full agonist 8.9 pKi 29
pKi 8.9 (Ki 1.26x10-9 M) [29]
zolmitriptan Hs Full agonist 8.9 pKi 29
pKi 8.9 [29]
lysergic acid Hs Full agonist 8.8 – 9.0 pKi 20
pKi 8.8 – 9.0 [20]
GR 127935 Hs Partial agonist 8.6 – 9.1 pKi 9,16,36,43,48
pKi 8.6 – 9.1 [9,16,36,43,48]
naratriptan Hs Full agonist 8.4 – 9.0 pKi 7,29,38
pKi 8.4 – 9.0 [7,29,38]
CGS-12066 Hs Full agonist 8.5 – 8.6 pKi 12,49
pKi 8.5 – 8.6 [12,49]
5-hydroxytryptamine Hs Full agonist 8.0 – 9.0 pKi 5,12,20,30,43,48-49
pKi 8.0 – 9.0 [5,12,20,30,43,48-49]
asenapine Hs Full agonist 8.4 pKi 42
pKi 8.4 [42]
frovatriptan Hs Agonist 8.4 pKi 54
pKi 8.4 (Ki 4.4x10-9 M) [54]
avitriptan Hs Agonist 8.4 pKi 41
pKi 8.4 (Ki 4.37x10-9 M) [41]
sumatriptan Hs Full agonist 8.0 – 8.7 pKi 12,20,25,29,49
pKi 8.0 – 8.7 (Ki 1x10-8 – 1.99x10-9 M) [12,20,25,29,49]
xanomeline Hs Full agonist 8.2 pKi 46
pKi 8.2 [46]
1-naphthylpiperazine Hs Full agonist 8.1 – 8.2 pKi 16,49
pKi 8.1 – 8.2 [16,49]
cabergoline Hs Partial agonist 8.1 pKi 24
pKi 8.1 [24]
5-MeOT Hs Full agonist 7.4 – 8.7 pKi 12,20,49
pKi 7.4 – 8.7 [12,20,49]
bromocriptine Hs Partial agonist 8.0 pKi 24
pKi 8.0 [24]
BRL-15572 Hs Partial agonist 7.9 pKi 36
pKi 7.9 [36]
pergolide Hs Partial agonist 7.9 pKi 24
pKi 7.9 [24]
rizatriptan Hs Full agonist 7.9 pKi 29
pKi 7.9 [29]
terguride Hs Partial agonist 7.8 pKi 24
pKi 7.8 [24]
RU 24969 Hs Full agonist 7.7 pKi 12
pKi 7.7 [12]
SB 216641 Hs Partial agonist 7.6 pKi 36
pKi 7.6 [36]
aripiprazole Hs Full agonist 7.2 pKi 44
pKi 7.2 [44]
dimethyltryptamine Hs Full agonist 7.0 – 7.3 pKi 20
pKi 7.0 – 7.3 [20]
TFMPP Hs Full agonist 7.1 – 7.2 pKi 12,49
pKi 7.1 – 7.2 [12,49]
8-OH-DPAT Hs Full agonist 6.9 – 7.3 pKi 7,20,29
pKi 6.9 – 7.3 [7,20,29]
tryptamine Hs Full agonist 6.8 – 7.4 pKi 20,49
pKi 6.8 – 7.4 [20,49]
roxindole Hs Partial agonist 7.0 – 7.2 pKi 24,30
pKi 7.0 – 7.2 [24,30]
EMDT Hs Full agonist 6.5 pKi 10
pKi 6.5 [10]
clozapine Hs Full agonist 6.4 pKi 42
pKi 6.4 [42]
α-methyl-5-HT Hs Full agonist 6.1 – 6.6 pKi 20
pKi 6.1 – 6.6 [20]
LY344864 Hs Full agonist 6.2 pKi 32
pKi 6.2 [32]
olanzapine Hs Full agonist 6.2 pKi 42
pKi 6.2 [42]
2-methyl-5-HT Hs Full agonist 5.7 – 6.2 pKi 20,49
pKi 5.7 – 6.2 [20,49]
quetiapine Hs Full agonist 5.7 pKi 42
pKi 5.7 [42]
capeserod Hs Partial agonist 5.1 pKi 27
pKi 5.1 [27]
dipropyl-5-CT Hs Full agonist 7.9 pIC50 49
pIC50 7.9 [49]
almotriptan Hs Agonist 7.9 pIC50 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
Description: Affinity of almotriptan at recombinant h5-HT1D receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer.
CP-122288 Hs Full agonist 7.7 pIC50 7
pIC50 7.7 [7]
View species-specific agonist tables
Agonist Comments
Frovatriptan is selective for 1B and 1D 5-HT receptor subtypes over the 1A subtype [54].
BRL-15572 can be used to distinguish between 5-HT1D and 5-HT1B receptors, being approximately 60-fold selective for the 1D subtype [36].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]GR 125,743 Hs Antagonist 8.6 pKd 53
pKd 8.6 (Kd 2.8x10-9 M) [53]
zotepine Hs Antagonist 9.3 pKi 42
pKi 9.3 [42]
SB 714786 Hs Antagonist 9.1 pKi 45
pKi 9.1 (Ki 7.94x10-10 M) [45]
metergoline Hs Antagonist 8.6 – 9.2 pKi 7,12,20
pKi 8.6 – 9.2 [7,12,20]
SB 649915 Hs Antagonist 8.8 pKi 45
pKi 8.8 [45]
ocaperidone Hs Antagonist 8.7 – 8.8 pKi 20
pKi 8.7 – 8.8 [20]
SB 272183 Hs Antagonist 8.7 pKi 47
pKi 8.7 [47]
methysergide Hs Antagonist 8.4 – 8.9 pKi 20,49
pKi 8.4 – 8.9 [20,49]
GR 127935 Hs Antagonist 8.3 – 8.6 pKi 20
pKi 8.3 – 8.6 [20]
9-OH-risperidone Hs Antagonist 7.9 pKi 42
pKi 7.9 [42]
risperidone Hs Antagonist 7.8 – 8.0 pKi 20,42
pKi 7.8 – 8.0 [20,42]
bufotenine Hs Antagonist 7.7 – 8.0 pKi 20
pKi 7.7 – 8.0 [20]
rauwolscine Hs Antagonist 7.8 pKi 49
pKi 7.8 [49]
methiothepin Hs Inverse agonist 7.3 – 8.2 pKi 7,12,20,48
pKi 7.3 – 8.2 [7,12,20,48]
ritanserin Hs Antagonist 7.6 pKi 20
pKi 7.6 [20]
(+)-WAY 100135 Hs Antagonist 7.6 pKi 5
pKi 7.6 [5]
ketanserin Hs Antagonist 7.4 – 7.5 pKi 7,20
pKi 7.4 – 7.5 [7,20]
yohimbine Hs Antagonist 7.2 – 7.7 pKi 12,20,25,49
pKi 7.2 – 7.7 [12,20,25,49]
sertindole Hs Antagonist 7.2 pKi 42
pKi 7.2 [42]
cyanopindolol Hs Antagonist 7.1 pKi 12
pKi 7.1 [12]
S33084 Hs Antagonist 6.9 pKi 23
pKi 6.9 [23]
pipamperone Hs Antagonist 6.8 pKi 42
pKi 6.8 [42]
m-chlorophenylpiperazine Hs Antagonist 6.7 pKi 12
pKi 6.7 [12]
haloperidol Hs Antagonist 6.6 pKi 42
pKi 6.6 [42]
SB 224289 Hs Antagonist 6.3 pKi 9,43
pKi 6.3 [9,43]
fluspirilene Hs Antagonist 6.0 pKi 42
pKi 6.0 [42]
SB 277011-A Hs Antagonist 5.8 pKi 37
pKi 5.8 [37]
spiperone Hs Antagonist 5.5 – 6.0 pKi 12,49
pKi 5.5 – 6.0 [12,49]
MPDT Hs Antagonist 5.2 pKi 10
pKi 5.2 [10]
L-772,405 Hs Antagonist 9.0 pIC50 40
pIC50 9.0 [40]
vortioxetine Rn Antagonist 5.4 pIC50 13
pIC50 5.4 (IC50 4x10-6 M) [13]
View species-specific antagonist tables
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
5-HT-moduline Hs Negative 12.0 pIC50 39
pIC50 12.0 [39]
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  12,21
Tissue Distribution
Trigeminal ganglion.
Species:  Human
Technique:  immunocytochemistry.
References:  14
Spinal cord: dorsal horn > ventral horn.
Species:  Human
Technique:  Radioligand binding.
References:  17
Poorly expressed in coronary arteries, atrium, ventricle and epicardium.
Species:  Human
Technique:  RT-PCR.
References:  31
Benign and malignant prostate tissue.
Species:  Human
Technique:  Western blotting.
References:  6
Globus pallidus > frontal cortex > putamen.
Species:  Human
Technique:  Radioligand binding.
References:  26
Trigeminal ganglion.
Species:  Rat
Technique:  Immunohistochemistry.
References:  22
Dorsal root ganglion and trigeminal ganglion.
Species:  Rat
Technique:  immunocytochemistry.
References:  35
Lumbar dorsal root ganglia, superior cervical ganglia, lumbar sympathetic ganglia.
Species:  Rat
Technique:  RT-PCR.
References:  33
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP levels in mouse adrenal Y-1 cells transfected with the 5-HT1D receptor.
Species:  Human
Tissue:  Y-1 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  49
Physiological Functions
Growth hormone release.
Species:  Human
Tissue:  In vivo.
References:  28,51
Inhibition of 5-HT release.
Species:  Rat
Tissue:  in vivo and mesencephalic raphe slices.
References:  34
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Htr1dtm1Lex Htr1dtm1Lex/Htr1dtm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
MGI:96276  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants
Type:  Single nucleotide polymorphisms
Species:  Human
Description:  Three polymorphisms, 1123 T -> G, 628 T-> C and 2190 A -> G have a possible association with anorexia nervosa.
References:  1

References

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1. Bergen AW, van den Bree MB, Yeager M, Welch R, Ganjei JK, Haque K, Bacanu S, Berrettini WH, Grice DE, Goldman D et al.. (2003) Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Mol. Psychiatry, 8 (4): 397-406. [PMID:12740597]

2. Bou J, Domènech T, Puig J, Heredia A, Gras J, Fernández-Forner D, Beleta J, Palacios JM. (2000) Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur. J. Pharmacol., 410 (1): 33-41. [PMID:11134654]

3. Boulenguez P, Segu L, Chauveau J, Morel A, Lanoir J, Delaage M. (1992) Biochemical and pharmacological characterization of serotonin-O-carboxymethylglycyl[125I]iodotyrosinamide, a new radioiodinated probe for 5-HT1B and 5-HT1D binding sites. J. Neurochem., 58 (3): 951-9. [PMID:1738002]

4. Bruinvels AT, Palacios JM, Hoyer D. (1993) Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedebergs Arch. Pharmacol., 347 (6): 569-82. [PMID:8361548]

5. Davidson C, Ho M, Price GW, Jones BJ, Stamford JA. (1997) (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. Br. J. Pharmacol., 121 (4): 737-42. [PMID:9208142]

6. Dizeyi N, Bjartell A, Nilsson E, Hansson J, Gadaleanu V, Cross N, Abrahamsson PA. (2004) Expression of serotonin receptors and role of serotonin in human prostate cancer tissue and cell lines. Prostate, 59 (3): 328-36. [PMID:15042609]

7. Doménech T, Beleta J, Palacios JM. (1997) Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Naunyn Schmiedebergs Arch. Pharmacol., 356 (3): 328-34. [PMID:9303569]

8. Ennis MD, Ghazal NB, Hoffman RL, Smith MW, Schlachter SK, Lawson CF, Im WB, Pregenzer JF, Svensson KA, Lewis RA et al.. (1998) Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J. Med. Chem., 41 (13): 2180-3. [PMID:9632349]

9. Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR et al.. (1998) The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J. Med. Chem., 41 (8): 1218-35. [PMID:9548813]

10. Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. (2000) 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J. Med. Chem., 43 (5): 1011-8. [PMID:10715164]

11. Hamblin MW, McGuffin RW, Metcalf MA, Dorsa DM, Merchant KM. (1992) Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors. Mol. Cell. Neurosci., 3: 578-587.

12. Hamblin MW, Metcalf MA. (1991) Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol. Pharmacol., 40 (2): 143-8. [PMID:1652050]

13. Heinrich T, Böttcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, Van Amsterdam C. (2004) Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. J. Med. Chem., 47 (19): 4684-92. [PMID:15341484]

14. Hou M, Kanje M, Longmore J, Tajti J, Uddman R, Edvinsson L. (2001) 5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglion: co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase. Brain Res., 909 (1-2): 112-20. [PMID:11478927]

15. John GW, Pauwels PJ, Perez M, Halazy S, Le Grand B, Verscheure Y, Valentin JP, Palmier C, Wurch T, Chopin P et al.. (1999) F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. J. Pharmacol. Exp. Ther., 290 (1): 83-95. [PMID:10381763]

16. Jorand-Lebrun C, Pauwels PJ, Palmier C, Moret C, Chopin P, Perez M, Marien M, Halazy S. (1997) 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J. Med. Chem., 40 (24): 3974-8. [PMID:9397179]

17. Laporte AM, Doyen C, Nevo IT, Chauveau J, Hauw JJ, Hamon M. (1996) Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord. J. Chem. Neuroanat., 11 (1): 67-75. [PMID:8841890]

18. Law H, Dukat M, Teitler M, Lee DK, Mazzocco L, Kamboj R, Rampersad V, Prisinzano T, Glennon RA. (1998) Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation. J. Med. Chem., 41 (13): 2243-51. [PMID:9632357]

19. Lesage AS, Wouters R, Van Gompel P, Heylen L, Vanhoenacker P, Haegeman G, Luyten WH, Leysen JE. (1998) Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br. J. Pharmacol., 123 (8): 1655-65. [PMID:9605573]

20. Leysen JE, Gommeren W, Heylen L, Luyten WH, Van de Weyer I, Vanhoenacker P, Haegeman G, Schotte A, Van Gompel P, Wouters R et al.. (1996) Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol. Pharmacol., 50 (6): 1567-80. [PMID:8967979]

21. Lin SL, Setya S, Johnson-Farley NN, Cowen DS. (2002) Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family. Br. J. Pharmacol., 136 (7): 1072-8. [PMID:12145108]

22. Ma QP. (2001) Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats. Neuroreport, 12 (8): 1589-91. [PMID:11409721]

23. Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, Lavielle G. (2000) S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. J. Pharmacol. Exp. Ther., 293 (3): 1048-62. [PMID:10869410]

24. Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther., 303 (2): 791-804. [PMID:12388666]

25. Millan MJ, Newman-Tancredi A, Audinot V, Cussac D, Lejeune F, Nicolas JP, Cogé F, Galizzi JP, Boutin JA, Rivet JM et al.. (2000) Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse, 35 (2): 79-95. [PMID:10611634]

26. Miller KJ, Teitler M. (1992) Quantitative autoradiography of 5-CT-sensitive (5-HT1D) and 5-CT-insensitive (5-HT1E) serotonin receptors in human brain. Neurosci. Lett., 136 (2): 223-6. [PMID:1641195]

27. Moser PC, Bergis OE, Jegham S, Lochead A, Duconseille E, Terranova JP, Caille D, Berque-Bestel I, Lezoualc'h F, Fischmeister R et al.. (2002) SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J. Pharmacol. Exp. Ther., 302 (2): 731-41. [PMID:12130738]

28. Mota A, Bento A, Peñalva A, Pombo M, Dieguez C. (1995) Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. J. Clin. Endocrinol. Metab., 80 (6): 1973-7. [PMID:7775648]

29. Napier C, Stewart M, Melrose H, Hopkins B, McHarg A, Wallis R. (1999) Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur. J. Pharmacol., 368 (2-3): 259-68. [PMID:10193663]

30. Newman-Tancredi A, Cussac D, Audinot V, Millan MJ. (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch. Pharmacol., 359 (6): 447-53. [PMID:10431754]

31. Nilsson T, Longmore J, Shaw D, Pantev E, Bard JA, Branchek T, Edvinsson L. (1999) Characterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques. Eur. J. Pharmacol., 372 (1): 49-56. [PMID:10374714]

32. Phebus LA, Johnson KW, Zgombick JM, Gilbert PJ, Van Belle K, Mancuso V, Nelson DL, Calligaro DO, Kiefer Jr AD, Branchek TA et al.. (1997) Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci., 61 (21): 2117-26. [PMID:9395253]

33. Pierce PA, Xie GX, Levine JD, Peroutka SJ. (1996) 5-Hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: a polymerase chain reaction study. Neuroscience, 70 (2): 553-9. [PMID:8848158]

34. Piñeyro G, de Montigny C, Blier P. (1995) 5-HT1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology, 13 (3): 249-60. [PMID:8602897]

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