isopentenyl diphosphate [Ligand Id: 3048] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL356362 (Isopentenylpyrophosphate, Isopentenyl Pyrophosphate)
  • butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481]
There should be some charts here, you may need to enable JavaScript!
  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
There should be some charts here, you may need to enable JavaScript!
  • TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8]
There should be some charts here, you may need to enable JavaScript!
  • mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
There should be some charts here, you may need to enable JavaScript!
  • farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481]
ChEMBL Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated IFNgamma production measured after 48 hrs by ELISA B 4.15 pEC50 71000 nM EC50 J Med Chem (2019) 62: 6814-6823 [PMID:31268699]
ChEMBL Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry B 4.44 pEC50 36000 nM EC50 J Med Chem (2019) 62: 6814-6823 [PMID:31268699]
ChEMBL Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells B 6 pEC50 1000 nM EC50 J Med Chem (2020) 63: 11258-11270 [PMID:32930595]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb Calcium imaging - 5.1 pIC50 - - - Br J Pharmacol (2010) 161: 707-20 [PMID:20880407]
TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8]
GtoPdb Calcium imaging - 6.62 pIC50 239 nM IC50 Pain (2011) 152: 1156-64 [PMID:21353389]
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb recombinant enzyme expressed in E coli cells. Spectrophotometric assay - 4.8 pKi 16000 nM Ki J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324]
GtoPdb value not verified - 6.15 pKi 700 nM - Meth Enzymol (1985) 110: 155-67 [PMID:4021811]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]