isopentenyl diphosphate [Ligand Id: 3048] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL356362 (Isopentenylpyrophosphate, Isopentenyl Pyrophosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| butyrophilin subfamily 3 member A1/Butyrophilin subfamily 3 member A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105758] [GtoPdb: 2948] [UniProtKB: O00481] | ||||||||
| ChEMBL | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated IFNgamma production measured after 48 hrs by ELISA | B | 4.15 | pEC50 | 71000 | nM | EC50 | J Med Chem (2019) 62: 6814-6823 [PMID:31268699] |
| ChEMBL | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry | B | 4.44 | pEC50 | 36000 | nM | EC50 | J Med Chem (2019) 62: 6814-6823 [PMID:31268699] |
| ChEMBL | Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells | B | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2020) 63: 11258-11270 [PMID:32930595] |
| TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
| GtoPdb | Calcium imaging | - | 5.1 | pIC50 | - | - | - | Br J Pharmacol (2010) 161: 707-20 [PMID:20880407] |
| TRPV3 in Human [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
| GtoPdb | Calcium imaging | - | 6.62 | pIC50 | 239 | nM | IC50 | Pain (2011) 152: 1156-64 [PMID:21353389] |
| mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] | ||||||||
| GtoPdb | recombinant enzyme expressed in E coli cells. Spectrophotometric assay | - | 4.8 | pKi | 16000 | nM | Ki | J Lipid Res (1997) 38: 2216-23 [PMID:9392419] |
| farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
| GtoPdb | value not verified | - | 6.15 | pKi | 700 | nM | - | Meth Enzymol (1985) 110: 155-67 [PMID:4021811] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
