Compound class:
Synthetic organic
Comment: The chemical structure for nivegacetor was obtained from WHO proposed INN list 131 (August 2024). The INN record describes the compound as a γ-secretase modulator. The catalytic subunit of the γ-secretase is PSEN1 (presenilin-1). Nivegacetor was developed for potential to slow amyloidogenesis in Alzheimer's disease [1]. The precise enantiomeric structure is difficult to idenitfy, but the SMILES provided for the CAS number (from the INN record) resolves to PubChem CID 153606610. Nivegacetor is predicted to be the INN for the Roche clinical stage γ-secretase modulator RG6289 [2].
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(7R)-7-(3,5-difluorophenoxy)-N-[(1S,5R)-3-(6-methoxypyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl]-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine |
Database Links ![]() |
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CAS Registry No. | 2443487-67-8 (source: WHO INN record) |
GtoPdb PubChem SID | 500839919 |
PubChem CID | 153606610 |
Search Google for chemical match using the InChIKey | YYYGNCPNCFDABE-QWUQOBSTSA-N |
Search Google for chemicals with the same backbone | YYYGNCPNCFDABE |
UniChem Compound Search for chemical match using the InChIKey | YYYGNCPNCFDABE-QWUQOBSTSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YYYGNCPNCFDABE-QWUQOBSTSA-N |