pyrogallol [Ligand Id: 13596] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307145 (NSC-5035, Pyrogallic acid, Pyrogallol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAMTS4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] | ||||||||
| ChEMBL | Inhibition of ADAMTS-4 (unknown origin) | B | 5.2 | pKi | 6340 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| ADAMTS5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] | ||||||||
| ChEMBL | Inhibition of ADAMTS-5 (unknown origin) | B | 5.44 | pKi | 3630 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | B | 5.67 | pIC50 | 2114 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | 5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) | F | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1997) 40: 3773-3780 [PMID:9371243] |
| Autoinducer 2-binding periplasmic protein luxP in Vibrio harveyi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6100] [UniProtKB: P54300] | ||||||||
| ChEMBL | Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer-2-mediated quorum sensing after 3 to 4 hrs | F | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1567-1572 [PMID:18262415] |
| Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] | ||||||||
| ChEMBL | Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay | B | 5.36 | pKi | 4390 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human CA1 using 4-nitrophenylacetate substrate by esterase assay | B | 5.13 | pKi | 7410 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human CA2 using 4-nitrophenylacetate substrate by esterase assay | B | 6.27 | pKi | 540 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522] |
| GtoPdb | - | - | 6.27 | pKi | 540 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-62 [PMID:21669522] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay | B | 6.28 | pKi | 520 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine by fluorescence based analysis | B | 5.05 | pIC50 | 8900 | nM | IC50 | J Med Chem (2023) 66: 1928-1940 [PMID:36701569] |
| ChEMBL | Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analysis | B | 5.17 | pIC50 | 6800 | nM | IC50 | J Med Chem (2023) 66: 1928-1940 [PMID:36701569] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) | B | 5.91 | pIC50 | 1230 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| ChEMBL | Inhibition of MMP12 (unknown origin) | B | 5.69 | pKi | 2030 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 (unknown origin) | B | 5.41 | pKi | 3890 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 (unknown origin) | B | 5.35 | pKi | 4430 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of MMP9 (unknown origin) | B | 5.15 | pKi | 7010 | nM | Ki | J Med Chem (2022) 65: 13505-13532 [PMID:36250680] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum | F | 5.25 | pIC50 | 5660 | nM | IC50 | J Med Chem (1995) 38: 2311-2316 [PMID:7608896] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) | B | 6 | pIC50 | 997 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
