ChEMBL ligand: CHEMBL307145 (NSC-5035, Pyrogallol)
MMP2/72 kDa type IV collagenase in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] There should be some charts here, you may need to enable JavaScript!
ADAMTS4/A disintegrin and metalloproteinase with thrombospondin motifs 4 in Human [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] There should be some charts here, you may need to enable JavaScript!
ADAMTS5/A disintegrin and metalloproteinase with thrombospondin motifs 5 in Human [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] There should be some charts here, you may need to enable JavaScript!
Arachidonate 5-lipoxygenase in Bovine [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] There should be some charts here, you may need to enable JavaScript!
Arginase-1 in Bovine [ChEMBL: CHEMBL1075060] [UniProtKB: Q2KJ64] There should be some charts here, you may need to enable JavaScript!
Autoinducer 2-binding periplasmic protein LuxP in Vibrio harveyi [ChEMBL: CHEMBL6100] [UniProtKB: P54300] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase 1 in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase 2 in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 6 in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
MMP12/Macrophage metalloelastase in Human [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] There should be some charts here, you may need to enable JavaScript!
MMP9/Matrix metalloproteinase-9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] There should be some charts here, you may need to enable JavaScript!
MMP8/Neutrophil collagenase in Human [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Polyunsaturated fatty acid lipoxygenase ALOX15 in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MMP2/72 kDa type IV collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL	Inhibition of MMP2 (unknown origin)	B	5.41	pKi	3890	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
ADAMTS4/A disintegrin and metalloproteinase with thrombospondin motifs 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173]
ChEMBL	Inhibition of ADAMTS-4 (unknown origin)	B	5.2	pKi	6340	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
ADAMTS5/A disintegrin and metalloproteinase with thrombospondin motifs 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0]
ChEMBL	Inhibition of ADAMTS-5 (unknown origin)	B	5.44	pKi	3630	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
ChEMBL	5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)	F	5.4	pIC50	4000	nM	IC50	J Med Chem (1997) 40: 3773-3780 [PMID:9371243]
Arginase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075060] [UniProtKB: Q2KJ64]
ChEMBL	Inhibition of bovine liver arginase 1 using L-arginine as substrate incubated for 60 mins by OPA-p colorimetric assay	B	3.43	pIC50	375000	nM	IC50	RSC Med Chem (2024) 15: 1722-1730 [PMID:38784454]
Autoinducer 2-binding periplasmic protein LuxP in Vibrio harveyi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6100] [UniProtKB: P54300]
ChEMBL	Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer-2-mediated quorum sensing after 3 to 4 hrs	F	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1567-1572 [PMID:18262415]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL	Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay	B	5.36	pKi	4390	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate substrate by esterase assay	B	5.13	pKi	7410	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate substrate by esterase assay	B	6.27	pKi	540	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
GtoPdb	-	-	6.27	pKi	540	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-62 [PMID:21669522]
Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay	B	6.28	pKi	520	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine by fluorescence based analysis	B	5.05	pIC50	8900	nM	IC50	J Med Chem (2023) 66: 1928-1940 [PMID:36701569]
ChEMBL	Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analysis	B	5.17	pIC50	6800	nM	IC50	J Med Chem (2023) 66: 1928-1940 [PMID:36701569]
epidermal growth factor receptor/Epidermal growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))	B	5.91	pIC50	1230	nM	IC50	DrugMatrix in vitro pharmacology data
MMP12/Macrophage metalloelastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900]
ChEMBL	Inhibition of MMP12 (unknown origin)	B	5.69	pKi	2030	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
MMP9/Matrix metalloproteinase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL	Inhibition of MMP9 (unknown origin)	B	5.15	pKi	7010	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
MMP8/Neutrophil collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL	Inhibition of MMP8 (unknown origin)	B	5.35	pKi	4430	nM	Ki	J Med Chem (2022) 65: 13505-13532 [PMID:36250680]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum	F	5.25	pIC50	5660	nM	IC50	J Med Chem (1995) 38: 2311-2316 [PMID:7608896]
Polyunsaturated fatty acid lipoxygenase ALOX15 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.67	pIC50	2114	nM	IC50	DrugMatrix in vitro pharmacology data
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))	B	6	pIC50	997	nM	IC50	DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]