ChEMBL ligand: CHEMBL163 (A-84538, ABBOTT-84538, ABT-538, Empetus, Norvir, NSC-693184, Ritomune, Ritonavir, Ritonavir related compounds mixture, Ritonavirum, Ritovir, Viekirax, Viriton)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
CYP2C9/Cytochrome P450 2C9 in Human [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] There should be some charts here, you may need to enable JavaScript!
CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] There should be some charts here, you may need to enable JavaScript!
CYP3A4/Cytochrome P450 3A4 in Human [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] There should be some charts here, you may need to enable JavaScript!
MATE2/Multidrug and toxin extrusion protein 2 in Human [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii yoelii [ChEMBL: CHEMBL612328] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] There should be some charts here, you may need to enable JavaScript!
CYP3A5 in Human [GtoPdb: 1338] [UniProtKB: P20815] There should be some charts here, you may need to enable JavaScript!
UDP glucuronosyltransferase family 1 member A1 in Human [GtoPdb: 2990] [UniProtKB: P22309] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	TP_TRANSPORTER: increase in mitoxantrone intracellular accumulation in BCRP-expressing HEK cells	F	4.71	pIC50	19500	nM	IC50	J Pharmacol Exp Ther (2004) 310: 334-341 [PMID:15007102]
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	Binding affinity to NTCP (unknown origin)	B	4.74	pKi	18400	nM	Ki	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712]
ChEMBL	DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	7.8	pIC50	16	nM	IC50	DrugMatrix in vitro pharmacology data
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL	DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	4.3	pIC50	50000	nM	IC50	DrugMatrix in vitro pharmacology data
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
GtoPdb	-	-	7	pKi	<100	nM	Ki	Antimicrob Agents Chemother (2008) 52: 1663-9 [PMID:18285471]
ChEMBL	DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)	B	7.8	pIC50	16	nM	IC50	DrugMatrix in vitro pharmacology data
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Equilibrium constant for the interaction between inhibitor and HIV-1 Protease	B	9.22	pKd	0.61	nM	Kd	J Med Chem (2002) 45: 5430-5439 [PMID:12459011]
ChEMBL	Binding affinity for human immunodeficiency virus type 1 protease	B	9.22	pKd	0.6	nM	Kd	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)	B	7.22	pKi	60	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)	B	7.4	pKi	40	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)	B	7.64	pKi	23	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Inhibitory concentration against HIV-1 protease	B	9.09	pKi	0.82	nM	Ki	J Med Chem (2001) 44: 3083-3091 [PMID:11543677]
ChEMBL	Inhibition constant against HIV-1 Protease	B	9.23	pKi	0.59	nM	Ki	J Med Chem (2002) 45: 5430-5439 [PMID:12459011]
ChEMBL	Inhibition constant for human immunodeficiency virus type 1 protease	B	9.23	pKi	0.59	nM	Ki	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Binding affinity to inhibit the purified wild-type HIV-1 Protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1997) 40: 181-191 [PMID:9003516]
ChEMBL	Binding affinity for HIV -1 Protease	B	9.43	pKi	0.37	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3217-3220 [PMID:10576691]
ChEMBL	Affinity against HIV protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1997) 40: 4079-4088 [PMID:9406598]
ChEMBL	Inhibitory activity against HIV-1 protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1996) 39: 4299-4312 [PMID:8863807]
ChEMBL	Tested for inhibitor binding of D25N/V82A mutant of HIV PR	B	9.92	pKi	0.12	nM	Ki	J Med Chem (2004) 47: 2030-2036 [PMID:15056001]
ChEMBL	Dissociation constant obtained by inhibition of Wild-type protease	B	10.21	pKi	0.06	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Inhibition of HIV protease	B	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1159-1162 [PMID:10866371]
ChEMBL	Inhibitory activity against purified HIV protease	B	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (1995) 5: 2725-2728
ChEMBL	Binding affinity to HIV1 protease assessed as inhibition constant	B	10.82	pKi	0.01	nM	Ki	J Med Chem (2016) 59: 5172-5208 [PMID:26799988]
ChEMBL	Tested for inhibitor binding of wild-type HIV PR	B	10.82	pKi	0.01	nM	Ki	J Med Chem (2004) 47: 2030-2036 [PMID:15056001]
ChEMBL	Inhibition constant of ritonavir towards HIV protease was determined	B	10.82	pKi	0.01	nM	Ki	Bioorg Med Chem Lett (1997) 7: 699-704
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	5.26	pKi	5462	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.86	pIC50	13655	nM	IC50	DrugMatrix in vitro pharmacology data
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	5.36	pIC50	4400	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis	B	7.1	pIC50	80	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
ChEMBL	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	4.63	pIC50	23700	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay	B	5.36	pIC50	4400	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.58	pKi	26606	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.18	pIC50	65542	nM	IC50	DrugMatrix in vitro pharmacology data
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	6.06	pKi	874	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	5.58	pIC50	2622	nM	IC50	DrugMatrix in vitro pharmacology data
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells	B	4.4	pIC50	39600	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3498-3504 [PMID:17664327]
ChEMBL	TP_TRANSPORTER: inhibition of cyclosporin A uptake (cyclosporin A: 10 uM) in MDR1-expressing LLC-PK1 cells	F	4.8	pIC50	15700	nM	IC50	J Pharmacol Exp Ther (2003) 304: 1161-1171 [PMID:12604693]
ChEMBL	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.92	pIC50	12000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	F	4.92	pIC50	12000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells	F	5.42	pIC50	3800	nM	IC50	Drug Metab Dispos (2000) 28: 655-660 [PMID:10820137]
ChEMBL	Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC	F	5.82	pIC50	1500	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	F	4.3	pIC50	50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5]
ChEMBL	Inhibition of Plasmodium falciparum DC6 plasmepsin-5 using DABCYL-GNKRTLAQKQG-EDANS as substrate measured every 15 mins of 75 mins by fluorescence assay	B	4.7	pIC50	>20000	nM	IC50	ACS Med Chem Lett (2014) 5: 89-93 [PMID:24900778]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	4.79	pIC50	16230	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	5.01	pIC50	9664	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antimalarial activity against Plasmodium falciparum FAC8	F	5.15	pEC50	7000	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring HFP-tagged Pfs16 protein after 48 hrs	F	5.3	pEC50	5000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs	F	5.52	pEC50	3000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs	F	5.52	pEC50	3000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10	F	5.96	pEC50	1100	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2	F	6.07	pEC50	850	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL	Antimicrobial activity against Plasmodium vivax at trophozoite stage	F	5.65	pIC50	2233	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328]
ChEMBL	Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs	F	7.47	pIC50	34.2	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2010) 53: 607-615 [PMID:19961222]
ChEMBL	Inhibition of HIV1 protease using fluorogenic hexapeptide substrate (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg by fluorimeter	B	9.5	pKi	0.31	nM	Ki	Medchemcomm (2011) 2: 1093-1098
ChEMBL	Inhibition of HIV1 protease	B	10.01	pKi	0.1	nM	Ki	Bioorg Med Chem (2008) 16: 1299-1308 [PMID:17981045]
ChEMBL	Inhibition of HIV1 protease	B	10.47	pKi	0.03	nM	Ki	Antimicrob Agents Chemother (2007) 51: 4036-4043 [PMID:17638694]
ChEMBL	Inhibition of HIV1 protease	B	5.01	pIC50	9850	nM	IC50	Bioorg Med Chem (2013) 21: 1964-1971 [PMID:23415084]
ChEMBL	Inhibition of HIV-1 protease	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2014) 24: 989-994 [PMID:24411125]
ChEMBL	Inhibition of HIV1 3B protease infected in human MT4 cells assessed as protection from virus induced cytopathogenicity measured after 5 days post infection by MTT assay	B	6.82	pEC50	150	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2379-2381 [PMID:29934245]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 MPro	B	4.7	pIC50	>20000	nM	IC50	Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	B	4.47	pIC50	33900	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	B	4.61	pIC50	24800	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)	B	7.12	pIC50	76	nM	IC50	DrugMatrix in vitro pharmacology data
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL	DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)	B	5.3	pKi	4981	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)	B	4.91	pIC50	12416	nM	IC50	DrugMatrix in vitro pharmacology data
CYP3A5 in Human [GtoPdb: 1338] [UniProtKB: P20815]
GtoPdb	-	-	6.92	pKi	120	nM	Ki	Curr Drug Metab (2005) 6: 413-54 [PMID:16248836]
UDP glucuronosyltransferase family 1 member A1 in Human [GtoPdb: 2990] [UniProtKB: P22309]
GtoPdb	-	-	5.77	pIC50	1700	nM	IC50	Drug Metab Dispos (2011) 39: 322-9 [PMID:21030469]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]