Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	-		CYP2D6	cytochrome P450 family 2 subfamily D member 6

Previous and Unofficial Names

Debrisoquine 4-hydroxylase | cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 | cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 | cytochrome P450, subfamily 2D, polypeptide 6 | cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 | cytochrome P450, family 2, subfamily D, polypeptide 6

Database Links
BRENDA	1.14.14.1
ChEMBL Target	CHEMBL289 (Hs)
Ensembl Gene	ENSG00000100197 (Hs)
Entrez Gene	1565 (Hs)
Human Protein Atlas	ENSG00000100197 (Hs)
KEGG Enzyme	1.14.14.1
KEGG Gene	hsa:1565 (Hs)
OMIM	124030 (Hs)
SynPHARM	82697 (in complex with ajmalicine)
UniProtKB	P10635 (Hs)
Wikipedia	CYP2D6 (Hs)

Enzyme Reaction
EC Number: 1.14.14.1

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference bufuralol N/A - - 1

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ajmalicine Hs Inhibition 8.5 pKi 3 ⤷ pKi 8.5 (Ki 3.3x10-9 M) [3] TIQ-15 Hs Inhibition 6.5 pIC50 2 ⤷ pIC50 6.5 (IC50 3.2x10-7 M) [2] compound 46c [PMID: 29350534] Hs Inhibition 5.6 pIC50 2 ⤷ pIC50 5.6 (IC50 2.61x10-6 M) [2]