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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 497 | 22q13.2 | CYP2D6 | cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) |
Database Links | |
Alphafold | P10635 (Hs) |
BRENDA | 1.14.14.1 |
ChEMBL Target | CHEMBL289 (Hs) |
Ensembl Gene | ENSG00000100197 (Hs) |
Entrez Gene | 1565 (Hs) |
Human Protein Atlas | ENSG00000100197 (Hs) |
KEGG Enzyme | 1.14.14.1 |
KEGG Gene | hsa:1565 (Hs) |
OMIM | 124030 (Hs) |
Pharos | P10635 (Hs) |
SynPHARM | 82697 (in complex with ajmalicine) |
UniProtKB | P10635 (Hs) |
Wikipedia | CYP2D6 (Hs) |
Enzyme Reaction | ||||
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Substrates and Reaction Kinetics | ||||||||||||||||||||||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Kim HG, Lee HS, Jeon JS, Choi YJ, Choi YJ, Yoo SY, Kim EY, Lee K, Park I, Na M et al.. (2020) Quasi-Irreversible Inhibition of CYP2D6 by Berberine. Pharmaceutics, 12 (10). DOI: 10.3390/pharmaceutics12100916 [PMID:32987920]
2. Lindmark B, Lundahl A, Kanebratt KP, Andersson TB, Isin EM. (2018) Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s. Br J Pharmacol, 175 (11): 2116-2129. [PMID:29574682]
3. Miller EJ, Jecs E, Truax VM, Katzman BM, Tahirovic YA, Wilson RJ, Kuo KM, Kim MB, Nguyen HH, Saindane MT et al.. (2018) Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties. J Med Chem, 61 (3): 946-979. [PMID:29350534]
4. Strobl GR, von Kruedener S, Stöckigt J, Guengerich FP, Wolff T. (1993) Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem, 36 (9): 1136-45. [PMID:8487254]