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- CYP2 family
CYP2 family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Enzymes
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CYP2A6
C
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CYP2A7 C Show summary »« Hide summary
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CYP2A13 Show summary »« Hide summary
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CYP2B6
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CYP2C8
C
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CYP2C9
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CYP2C18 Show summary »« Hide summary
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CYP2C19 Show summary »« Hide summary
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CYP2D6
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CYP2E1
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CYP2F1 Show summary »« Hide summary
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CYP2J2 C Show summary »« Hide summary
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CYP2R1 C Show summary »« Hide summary
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CYP2S1 Show summary »« Hide summary
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CYP2U1 Show summary »« Hide summary
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CYP2W1 Show summary »« Hide summary
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References
1. Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. (2003) De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J. Biol. Chem., 278 (39): 38084-93. [PMID:12867411]
2. Crosignani S, Jorand-Lebrun C, Campbell G, Pretre A, Grippi-Vallotton, T, Quattropani, A, Bouscary-Desforges G, Bombrun A, Missotten, M, Humbert Y et al.. (2011) Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids. ACS Med Chem Lett, 2: 938-942.
3. Fontana E, Dansette PM, Poli SM. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr. Drug Metab., 6 (5): 413-54. [PMID:16248836]
4. Foti RS, Rock DA, Han X, Flowers RA, Wienkers LC, Wahlstrom JL. (2012) Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19. J. Med. Chem., 55 (3): 1205-14. [PMID:22239545]
5. Fukami T, Nakajima M, Sakai H, McLeod HL, Yokoi T. (2006) CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele. Pharmacogenomics J., 6 (6): 401-12. [PMID:16636685]
6. Ha-Duong NT, Dijols S, Marques-Soares C, Minoletti C, Dansette PM, Mansuy D. (2001) Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. J. Med. Chem., 44 (22): 3622-31. [PMID:11606127]
7. Lafite P, Dijols S, Buisson D, Macherey AC, Zeldin DC, Dansette PM, Mansuy D. (2006) Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. Bioorg. Med. Chem. Lett., 16 (10): 2777-80. [PMID:16495056]
8. Lindmark B, Lundahl A, Kanebratt KP, Andersson TB, Isin EM. (2018) Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s. Br. J. Pharmacol., 175 (11): 2116-2129. [PMID:29574682]
9. Peng CC, Rushmore T, Crouch GJ, Jones JP. (2008) Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9. Bioorg. Med. Chem., 16 (7): 4064-74. [PMID:18255300]
10. Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC. (1996) Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J. Biol. Chem., 271 (7): 3460-8. [PMID:8631948]
11. Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J. Med. Chem., 49 (24): 6987-7001. [PMID:17125252]
12. Zeldin DC, DuBois RN, Falck JR, Capdevila JH. (1995) Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch. Biochem. Biophys., 322 (1): 76-86. [PMID:7574697]
How to cite this family page
Database page citation:
CYP2 family. Accessed on 22/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=262.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.
