Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	493	10q26.3	CYP2E1	cytochrome P450 family 2 subfamily E member 1
Mouse	-	493	7 85.94 cM	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1
Rat	-	493	1q41	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1

Previous and Unofficial Names

4-nitrophenol 2-hydroxylase | cytochrome P450 2E1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | cytochrome P450, subfamily 2e1 (ethanol-inducible) | cytochrome P450, family 2, subfamily E, polypeptide 1 | cytochrome P450

Database Links
Alphafold	P05181 (Hs), Q05421 (Mm), P05182 (Rn)
BRENDA	1.14.14.1
ChEMBL Target	CHEMBL5281 (Hs), CHEMBL5978 (Rn)
Ensembl Gene	ENSG00000130649 (Hs), ENSMUSG00000025479 (Mm), ENSRNOG00000012458 (Rn)
Entrez Gene	1571 (Hs), 13106 (Mm), 25086 (Rn)
Human Protein Atlas	ENSG00000130649 (Hs)
KEGG Enzyme	1.14.14.1
KEGG Gene	hsa:1571 (Hs), mmu:13106 (Mm), rno:25086 (Rn)
OMIM	124040 (Hs)
Pharos	P05181 (Hs)
UniProtKB	P05181 (Hs), Q05421 (Mm), P05182 (Rn)
Wikipedia	CYP2E1 (Hs)

Enzyme Reaction
EC Number: 1.14.14.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 23 [PMID: 17125252] Hs Inhibition 7.4 pKi 2 ⤷ pKi 7.4 (Ki 4x10-8 M) [2] 12-Imidazolyl-1-dodecanol Hs Inhibition 6.2 pKi 1 ⤷ pKi 6.2 [1]