CYP2C9 | CYP2 family | IUPHAR/BPS Guide to PHARMACOLOGY

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CYP2C9

Target not currently curated in GtoImmuPdb

Target id: 1326

Nomenclature: CYP2C9

Family: CYP2 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP2C9 cytochrome P450 family 2 subfamily C member 9
Previous and Unofficial Names
(R)-Limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | S-mephenytoin 4-hydroxylase | CYP2C10 | cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9 | cytochrome P450, family 2, subfamily C, polypeptide 9
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.14.51
Description Reaction Reference
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) <=> (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 18255300] Hs Inhibition 8.4 pKi 2
pKi 8.4 (Ki 4.2x10-9 M) [2]
compound 51 [Crosignani et al., 2011] Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]
noscapine N/A Inhibition - -
View species-specific inhibitor tables
General Comments
Cytochrome P450 2C9 (CYP2C9) is one of the three major drug metabolizing cytochrome P450 enzymes in human liver.

References

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1. Crosignani S, Jorand-Lebrun C, Campbell G, Pretre A, Grippi-Vallotton, T, Quattropani, A, Bouscary-Desforges G, Bombrun A, Missotten, M, Humbert Y et al.. (2011) Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids. ACS Med Chem Lett, 2: 938-942.

2. Peng CC, Rushmore T, Crouch GJ, Jones JP. (2008) Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9. Bioorg. Med. Chem., 16 (7): 4064-74. [PMID:18255300]

How to cite this page

CYP2 family: CYP2C9. Last modified on 04/02/2019. Accessed on 20/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1326.