tegafur

Ligand id: 10513

Name: tegafur

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 64.09
Molecular weight 200.06
XLogP 0.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (EMA (2011))
IUPAC Name
5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione
International Nonproprietary Names
INN number INN
4415 tegafur
Synonyms
Florafur® | FT-207 | FT207 | Ftorafur®
Comments
Like capecitabine and floxuridine, tegafur is a prodrug of the chemotherapeutic agent 5-fluorouracil. It is orally active. The INN specifies tegafur as a racemic mixture of enantiomers. We show the molecule without specified stereochemistry to represent the mixture.
Database Links
CAS Registry No. 17902-23-7 (source: WHO INN record)
ChEMBL Ligand CHEMBL20883
GtoPdb PubChem SID 387065595
PubChem CID 5386
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