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Synonyms: Florafur® | FT-207 | FT207 | Ftorafur®
tegafur is an approved drug (EMA (2011))
Compound class: Synthetic organic
Comment: Like capecitabine and floxuridine, tegafur is a prodrug of the chemotherapeutic agent 5-fluorouracil. It is orally active. The INN specifies tegafur as a racemic mixture of enantiomers. We show the molecule without specified stereochemistry to represent the mixture.
1. Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, Tarasenko I, Rephaeli A. (2008)
Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.
J Med Chem, 51 (2): 314-23. [PMID:18163551]