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UDP glucuronosyltransferase family 1 member A1

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Target not currently curated in GtoImmuPdb

Target id: 2990

Nomenclature: UDP glucuronosyltransferase family 1 member A1

Family: UDP glucuronosyltransferases (UGT)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 533 2q37.1 UGT1A1 UDP glucuronosyltransferase family 1 member A1
Mouse 1 535 1 44.55 cM Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1
Rat 1 535 9q35 Ugt1a1 UDP glucuronosyltransferase family 1 member A1
Gene and Protein Information Comments
The UGT1A1 gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Over 100 genetic variants within the UGT1A1 gene have been described, some of which confer increased, reduced or inactive enzymatic activity. The UGT nomenclature committee has compiled a list of these variants, naming each with a * symbol followed by a number. Many exogenous substances, mutagenic xenobiotics and therapeutic drugs are UGT1A1 substrates.
Previous and Unofficial Names Click here for help
UDP glucuronosyltransferase 1 family, polypeptide A1 | UDP glucuronosyltransferase 1 family
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Protein
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ritonavir Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.7x10-6 M) Both inhibitor and substrate [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0006953 acute-phase response IEA

References

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1. Zhou J, Tracy TS, Remmel RP. (2011) Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos, 39 (2): 322-9. [PMID:21030469]

How to cite this page

UDP glucuronosyltransferases (UGT): UDP glucuronosyltransferase family 1 member A1. Last modified on 05/03/2018. Accessed on 07/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2990.