Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	533	2q37.1	UGT1A1	UDP glucuronosyltransferase family 1 member A1
Mouse	1	535	1 44.55 cM	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1
Rat	1	535	9q35	Ugt1a1	UDP glucuronosyltransferase family 1 member A1
Gene and Protein Information Comments
The UGT1A1 gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Over 100 genetic variants within the UGT1A1 gene have been described, some of which confer increased, reduced or inactive enzymatic activity. The UGT nomenclature committee has compiled a list of these variants, naming each with a * symbol followed by a number. Many exogenous substances, mutagenic xenobiotics and therapeutic drugs are UGT1A1 substrates.

Previous and Unofficial Names

UDP glucuronosyltransferase 1 family, polypeptide A1 | UDP glucuronosyltransferase 1 family

Database Links
Alphafold	P22309 (Hs), Q63886 (Mm), Q64550 (Rn)
ChEMBL Target	CHEMBL1287617 (Hs), CHEMBL4523337 (Mm), CHEMBL4523339 (Rn)
Ensembl Gene	ENSG00000241635 (Hs), ENSMUSG00000089960 (Mm), ENSRNOG00000018740 (Rn)
Entrez Gene	54658 (Hs), 394436 (Mm), 24861 (Rn)
Human Protein Atlas	ENSG00000241635 (Hs)
KEGG Gene	hsa:54658 (Hs), mmu:394436 (Mm), rno:24861 (Rn)
OMIM	191740 (Hs)
Pharos	P22309 (Hs)
RefSeq Protein	NP_000454 (Hs), NP_964007 (Mm), NP_036815 (Rn)
UniProtKB	P22309 (Hs), Q63886 (Mm), Q64550 (Rn)
Wikipedia	UGT1A1 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ritonavir Hs Inhibition 5.8 pIC50 1 ⤷ pIC50 5.8 (IC50 1.7x10-6 M) Both inhibitor and substrate [1]

Immuno Process Associations

Immuno Process:  Inflammation