Organic cation transporter 2 | Organic cation transporters (OCT) | IUPHAR/BPS Guide to PHARMACOLOGY

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Organic cation transporter 2

Target not currently curated in GtoImmuPdb

Target id: 1020

Nomenclature: Organic cation transporter 2

Abbreviated Name: OCT2

Systematic Nomenclature: SLC22A2

Family: Organic cation transporters (OCT)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC22A2 solute carrier family 22 member 2
Mouse - - Slc22a2 solute carrier family 22 (organic cation transporter)
Rat - - Slc22a2 solute carrier family 22 member 2
Previous and Unofficial Names
OCT2r | organic cation transporter 2 | solute carrier family 22 (organic cation transporter), member 2 | Orct2 | solute carrier family 22 (organic cation transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A2 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
metformin Hs - - 2
cisplatin Hs - - 2

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
decynium 22 Hs Inhibition 7.0 pKi 1
pKi 7.0 (Ki 1x10-7 M) [1]
Description: Measuring inhibition of tetraethylammonium (TEA) uptake via OCT2 expressed in Xenopus oocytes.


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1. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol., 16 (7): 871-81. [PMID:9260930]

2. Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol. Aspects Med., 34 (2-3): 413-35. [PMID:23506881]


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