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Target not currently curated in GtoImmuPdb
Target id: 3106
Nomenclature: Plasmodium falciparum plasmepsin V
Abbreviated Name: PfPMV
Family: Antimalarial targets
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 590 | PMV | plasmepsin V |
Database Links ![]() |
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ChEMBL Target | CHEMBL3559649 (Pf3D7) |
PlasmoDB | PF3D7_1323500 (Pf3D7) |
UniProtKB | Q8I6Z5 (Pf3D7) |
Whole Organism Assay Data Linked to This Target | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Malaria Pharmacology Comments |
The P. falciparum genome encodes 10 aspartic proteases, classed together as the plasmepsin family, which are involved in diverse cellular processes [3]. The P. falciparum plasmepsin V (PfPMV) enzyme processes proteins for export into the host erythrocyte and has been shown to be essential for parasite asexual blood stage development [1-2]. PfPMV has also been shown to be essential for gametocyte development, validating it as a potential target for the development of transmission-blocking drugs [5]. |
1. Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, Pearce JA, de Koning-Ward TF, Simpson RJ, Crabb BS et al.. (2010) An aspartyl protease directs malaria effector proteins to the host cell. Nature, 463 (7281): 627-31. [PMID:20130643]
2. Boonyalai N, Collins CR, Hackett F, Withers-Martinez C, Blackman MJ. (2018) Essentiality of Plasmodium falciparum plasmepsin V. PLoS ONE, 13 (12): e0207621. [PMID:30517136]
3. Coombs GH, Goldberg DE, Klemba M, Berry C, Kay J, Mottram JC. (2001) Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol., 17 (11): 532-7. [PMID:11872398]
4. Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ et al.. (2015) Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes. Nat. Struct. Mol. Biol., 22 (8): 590-6. [PMID:26214367]
5. Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA. (2019) Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes. Cell Rep, 29 (12): 3796-3806.e4. [PMID:31851913]
Antimalarial targets: Plasmodium falciparum plasmepsin V. Last modified on 29/01/2020. Accessed on 23/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3106.