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Antimalarial targets

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This family encompasses antimalarial targets identified and validated in Plasmodium, the genus of protozoan parasite known to cause malaria. The genome of P. falciparum, the species that is responsible for the majority of malaria-related deaths, has been sequenced and analysed contributing to an increased understanding of potential biological targets in the parasite. More than half of the predicted gene products exhibit little homology outside the Plasmodium genus and have not been given functional assignments, while a considerable number are unique to P. falciparum [2]. In recent years, genetic methods have facilitated the identification of new molecular targets in the parasite and it is hoped that novel cross-lifecycle targets will be elucidated to help inform antimalarial drug discovery [1].

Targets

PfATP4 (Plasmodium falciparum ATPase4) Show summary » More detailed page

PfCARL (Plasmodium falciparum cyclic amine resistance locus) Show summary » More detailed page

PfCPSF3 (Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3) Show summary » More detailed page

PfCYTB (Plasmodium falciparum cytochrome b) Show summary » More detailed page

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) Show summary » More detailed page

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary » More detailed page

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) Show summary » More detailed page

PfeEF2 (Plasmodium falciparum elongation factor 2) Show summary » More detailed page

PfGWT1 (Plasmodium falciparum GPI-anchored wall transfer protein 1) Show summary » More detailed page

PfHDAC1 (Plasmodium falciparum histone deacetylase 1) Show summary » More detailed page

PfHDP (Plasmodium falciparum heme detoxification protein) Show summary » More detailed page

PfHT (Plasmodium falciparum hexose transporter) Show summary » More detailed page

PfIspD (Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) Show summary » More detailed page

PfNDH2 (Plasmodium falciparum type II NADH:ubiquinone oxidoreductase) Show summary » More detailed page

PfNMT (Plasmodium falciparum N-Myristoyltransferase) Show summary » More detailed page

PfPANK1 (Plasmodium falciparum pantothenate kinase 1) Show summary » More detailed page

PfPDEalpha (Plasmodium falciparum cGMP-specific phosphodiesterase) Show summary » More detailed page

PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase) Show summary » More detailed page

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) Show summary » More detailed page

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) Show summary » More detailed page

PfPMX (Plasmodium falciparum plasmepsin X) Show summary » More detailed page

Plasmodium falciparum proteasome subunit beta type-5 Show summary » More detailed page

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) Show summary » More detailed page

PfPPPK-DHPS (Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase) Show summary » More detailed page

PfSHMT (Plasmodium falciparum serine hydroxymethyltransferase) Show summary » More detailed page

PfKRS1 (Plasmodium falciparum lysine--tRNA ligase) Show summary » More detailed page

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary » More detailed page

PfPRS (Plasmodium falciparum proline--tRNA ligase) Show summary » More detailed page

PfThrRS (Plasmodium falciparum threonine--tRNA ligase) Show summary » More detailed page

Plasmodium falciparum V-type proton ATPase Show summary » More detailed page

Further reading

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References

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How to cite this family page

Database page citation:

Antimalarial targets. Accessed on 18/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.