Overview
This family encompasses antimalarial targets identified and validated in Plasmodium, the genus of protozoan parasite known to cause malaria. The genome of P. falciparum, the species that is responsible for the majority of malaria-related deaths, has been sequenced and analysed contributing to an increased understanding of potential biological targets in the parasite. More than half of the predicted gene products exhibit little homology outside the Plasmodium genus and have not been given functional assignments, while a considerable number are unique to P. falciparum [2]. In recent years, genetic methods have facilitated the identification of new molecular targets in the parasite and it is hoped that novel cross-lifecycle targets will be elucidated to help inform antimalarial drug discovery [1].
Subfamilies
How to cite this family page
Database page citation:
Antimalarial targets. Accessed on 09/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.
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