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Antimalarial targets

Overview

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This family encompasses antimalarial targets identified and validated in Plasmodium, the genus of protozoan parasite known to cause malaria. The genome of P. falciparum, the species that is responsible for the majority of malaria-related deaths, has been sequenced and analysed contributing to an increased understanding of potential biological targets in the parasite. More than half of the predicted gene products exhibit little homology outside the Plasmodium genus and have not been given functional assignments, while a considerable number are unique to P. falciparum [2]. In recent years, genetic methods have facilitated the identification of new molecular targets in the parasite and it is hoped that novel cross-lifecycle targets will be elucidated to help inform antimalarial drug discovery [1].

Targets

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PfATP4 (Plasmodium falciparum ATPase4) Show summary » More detailed page go icon to follow link

PfCARL (Plasmodium falciparum cyclic amine resistance locus) Show summary » More detailed page go icon to follow link

PfCLK3 (Plasmodium falciparum cyclin-dependent-like kinase CLK3) Show summary » More detailed page go icon to follow link

PfCPSF3 (Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3) Show summary » More detailed page go icon to follow link

PfCYTB (Plasmodium falciparum cytochrome b) Show summary » More detailed page go icon to follow link

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) Show summary » More detailed page go icon to follow link

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary » More detailed page go icon to follow link

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) Show summary » More detailed page go icon to follow link

PfeEF2 (Plasmodium falciparum elongation factor 2) Show summary » More detailed page go icon to follow link

PfGWT1 (Plasmodium falciparum GPI-anchored wall transfer protein 1) Show summary » More detailed page go icon to follow link

PfHDAC1 (Plasmodium falciparum histone deacetylase 1) Show summary » More detailed page go icon to follow link

PfHDP (Plasmodium falciparum heme detoxification protein) Show summary » More detailed page go icon to follow link

PfHT1 (Plasmodium falciparum hexose transporter) Show summary » More detailed page go icon to follow link

PfIspD (Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) Show summary » More detailed page go icon to follow link

PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein) Show summary » More detailed page go icon to follow link

PfNDH2 (Plasmodium falciparum type II NADH:ubiquinone oxidoreductase) Show summary » More detailed page go icon to follow link

PfNMT (Plasmodium falciparum N-Myristoyltransferase) Show summary » More detailed page go icon to follow link

PfPANK1 (Plasmodium falciparum pantothenate kinase 1) Show summary » More detailed page go icon to follow link

PfPDEalpha (Plasmodium falciparum cGMP-specific phosphodiesterase) Show summary » More detailed page go icon to follow link

PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase) Show summary » More detailed page go icon to follow link

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) Show summary » More detailed page go icon to follow link

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) Show summary » More detailed page go icon to follow link

PfPMV (Plasmodium falciparum plasmepsin V) Show summary » More detailed page go icon to follow link

PfPMX (Plasmodium falciparum plasmepsin X) Show summary » More detailed page go icon to follow link

Plasmodium falciparum proteasome subunit beta type-5 Show summary » More detailed page go icon to follow link

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) Show summary » More detailed page go icon to follow link

PfPPPK-DHPS (Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase) Show summary » More detailed page go icon to follow link

PfSHMT (Plasmodium falciparum serine hydroxymethyltransferase) Show summary » More detailed page go icon to follow link

PfKRS1 (Plasmodium falciparum lysine--tRNA ligase) Show summary » More detailed page go icon to follow link

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary » More detailed page go icon to follow link

PfPRS (Plasmodium falciparum proline--tRNA ligase) Show summary » More detailed page go icon to follow link

PfThrRS (Plasmodium falciparum threonine--tRNA ligase) Show summary » More detailed page go icon to follow link

Plasmodium falciparum V-type proton ATPase Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Antimalarial targets. Accessed on 22/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.