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This family encompasses antimalarial targets identified and validated in Plasmodium, the genus of protozoan parasite known to cause malaria. The genome of P. falciparum, the species that is responsible for the majority of malaria-related deaths, has been sequenced and analysed contributing to an increased understanding of potential biological targets in the parasite. More than half of the predicted gene products exhibit little homology outside the Plasmodium genus and have not been given functional assignments, while a considerable number are unique to P. falciparum [2]. In recent years, genetic methods have facilitated the identification of new molecular targets in the parasite and it is hoped that novel cross-lifecycle targets will be elucidated to help inform antimalarial drug discovery [1].
PfATP4 (Plasmodium falciparum ATPase4)
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PfCARL (Plasmodium falciparum cyclic amine resistance locus)
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PfCLK3 (Plasmodium falciparum cyclin-dependent-like kinase CLK3)
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PfCPSF3 (Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3)
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PfCYTB (Plasmodium falciparum cytochrome b)
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PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase)
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PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)
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PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase)
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PfeEF2 (Plasmodium falciparum elongation factor 2)
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PfGWT1 (Plasmodium falciparum GPI-anchored wall transfer protein 1)
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PfHDAC1 (Plasmodium falciparum histone deacetylase 1)
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PfHDP (Plasmodium falciparum heme detoxification protein)
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PfHT1 (Plasmodium falciparum hexose transporter)
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PfIspD (Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase)
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PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein)
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PfNDH2 (Plasmodium falciparum type II NADH:ubiquinone oxidoreductase)
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PfNMT (Plasmodium falciparum N-Myristoyltransferase)
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PfPANK1 (Plasmodium falciparum pantothenate kinase 1)
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PfPDEalpha (Plasmodium falciparum cGMP-specific phosphodiesterase)
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PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase)
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PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase)
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PfPKG (Plasmodium falciparum cGMP-dependent protein kinase)
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PfPMV (Plasmodium falciparum plasmepsin V)
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PfPMX (Plasmodium falciparum plasmepsin X)
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Plasmodium falciparum proteasome subunit beta type-5
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PfPNP (Plasmodium falciparum purine nucleoside phosphorylase)
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PfPPPK-DHPS (Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase)
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PfSHMT (Plasmodium falciparum serine hydroxymethyltransferase)
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PfKRS1 (Plasmodium falciparum lysine--tRNA ligase)
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PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit)
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PfPRS (Plasmodium falciparum proline--tRNA ligase)
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PfThrRS (Plasmodium falciparum threonine--tRNA ligase)
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Plasmodium falciparum V-type proton ATPase
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Database page citation:
Antimalarial targets. Accessed on 22/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.