Overview
The aminoacyl-tRNA synthetases (aaRSs) are a large and diverse enzyme family with an essential role in the ATP-dependent aminoacylation of cognate tRNAs with their respective amino acids for use in protein synthesis [2]. The P. falciparum genome encodes 36 different aaRSs, which participate in both cytoplasmic and organellar protein synthesis and are emerging targets for antimalarial agents [1,3].
Targets
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PfaIRS (Plasmodium falciparum isoleucyl-tRNA synthetase)
C
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PfcKRS (Plasmodium falciparum lysyl-tRNA synthetase)
C
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PfcFRS (Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit)
C
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PfcPRS (Plasmodium falciparum prolyl-tRNA synthetase)
C
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PfTRS (Plasmodium falciparum threonyl-tRNA synthetase)
C
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PfaWRS (Plasmodium falciparum tryptophanyl-tRNA synthetase)
C
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How to cite this family page
Database page citation:
Aminoacyl-tRNA synthetases. Accessed on 25/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.
