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Aminoacyl-tRNA synthetases

Overview

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The aminoacyl-tRNA synthetases (aaRSs) are a large and diverse enzyme family with an essential role in the ATP-dependent aminoacylation of cognate tRNAs with their respective amino acids for use in protein synthesis [2]. The P. falciparum genome encodes 36 different aaRSs, which participate in both cytoplasmic and organellar protein synthesis and are emerging targets for antimalarial agents [1,3].

Targets

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PfaIRS (Plasmodium falciparum isoleucyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfcKRS (Plasmodium falciparum lysyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfcFRS (Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit) C Show summary » More detailed page go icon to follow link

PfcPRS (Plasmodium falciparum prolyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfTRS (Plasmodium falciparum threonyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfaWRS (Plasmodium falciparum tryptophanyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Aminoacyl-tRNA synthetases. Accessed on 07/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.