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Plasmodium falciparum isoleucyl-tRNA synthetase

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3168

Nomenclature: Plasmodium falciparum isoleucyl-tRNA synthetase

Abbreviated Name: PfaIRS

Family: Aminoacyl-tRNA synthetases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1696 api-IRS isoleucine--tRNA ligase, putative
Gene and Protein Information Comments
The Plasmodium genome encodes two forms of isoleucyl-tRNA synthetase, one found in the cytoplasm (PfcIRS, encoded by PF3D7_1332900) and one in the apicoplast (PfaIRS, described here).
Previous and Unofficial Names Click here for help
Pfapi-IRS | PFL1210w | Plasmodium falciparum isoleucine--tRNA ligase
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
mupirocin Small molecule or natural product Approved drug Guide to Malaria Pharmacology Ligand Pf3D7 - - 7.2 pIC50 1
pIC50 7.2 (IC50 5.74x10-8 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
P. falciparum isoleucyl-tRNA synthetase pairs isoleucine with its cognate tRNA and is categorized as a class I aaRS.

References

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1. Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. (2011) Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A, 108 (4): 1627-32. [PMID:21205898]

How to cite this page

Aminoacyl-tRNA synthetases: Plasmodium falciparum isoleucyl-tRNA synthetase. Last modified on 29/03/2022. Accessed on 25/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3168.