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Kinases (Plasmodium spp.)

Overview

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Kinases are a large family of enzymes responsible for the control of signal transduction pathways that regulate essential cellular processes in eukaryotic cells. The Plasmodium kinome is highly conserved across the genus but encodes a much smaller number of genes than that of the human kinome (see our Kinases Concise family page for more details of the latter). Both protein and lipid kinases are essential in signaling pathways during multiple stages of the parasite lifecycle and have emerged as attractive targets for antimalarial drug discovery [1].

Targets

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PfCLK3 (Plasmodium falciparum cyclin-dependent-like kinase CLK3) C Show summary » More detailed page go icon to follow link

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) C Show summary » More detailed page go icon to follow link

PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase) C Show summary » More detailed page go icon to follow link

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Kinases (Plasmodium spp.). Accessed on 15/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1054.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.