Overview
Kinases are a large family of enzymes responsible for the control of signal transduction pathways that regulate essential cellular processes in eukaryotic cells. The Plasmodium kinome is highly conserved across the genus but encodes a much smaller number of genes than that of the human kinome (see our Kinases Concise family page for more details of the latter) [1]. Both protein and lipid kinases are essential in signaling pathways during multiple stages of the parasite lifecycle and have emerged as attractive targets for antimalarial drug discovery [2-3].
Targets
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PfCLK3 (Plasmodium falciparum cyclin-dependent-like kinase CLK3)
C
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PfPKG (Plasmodium falciparum cGMP-dependent protein kinase)
C
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PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase)
C
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PfPI4Kβ (Plasmodium falciparum phosphatidylinositol 4-kinase beta)
C
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How to cite this family page
Database page citation:
Kinases (Plasmodium spp.). Accessed on 07/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1054.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.
