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Transporters (Plasmodium spp.)

Overview

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To survive and replicate during the intraerythrocytic lifecycle stages, the malaria parasite uses a range of transport processes to take up nutrients, export waste products, and maintain tight regulation over its own internal ionic environment [1]. Plasmodium membrane transport proteins are candidate targets for antimalarial drug discovery but have also been shown to play a role in the development of drug resistance.

Targets

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PfATP4 (Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase) C Show summary » More detailed page go icon to follow link

Plasmodium falciparum V-type proton ATPase subunit D C Show summary » More detailed page go icon to follow link

PfHT1 (Plasmodium falciparum hexose transporter) C Show summary » More detailed page go icon to follow link

PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Transporters (Plasmodium spp.). Accessed on 05/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1064.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.