Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	1283		CARL	cyclic amine resistance locus protein

Previous and Unofficial Names

CARL | Pf3D7_03_v3:921,776..928,618(+) | PFC0970w

Database Links
Alphafold	C0H483 (Pf3D7)
PlasmoDB	PF3D7_0321900 (Pf3D7)
UniProtKB	C0H483 (Pf3D7)

Malaria Pharmacology Comments

The P. falciparum cyclic amine resistance locus (PfCARL) encodes a seven-transmembrane domain protein that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages [1]. Homology analysis provides an insight into possible function: the S. cerevisiae homolog, Emp65, is a part of a molecular chaperone complex in the endoplasmic reticulum and the mouse homolog, Tapt1, is involved in embryonic skeletal formation, signal transduction, and hormone trafficking [1,3]. Mutations in PfCARL are associated with parasite resistance to two distinct compound classes: the imidazolopiperazines, a novel class of antimalarial compounds that includes the clinical candidate ganaplacide, and the benzimidazolyl piperidines, with the suggestion that PfCARL is a multidrug-resistance gene rather than the common target [1-2].