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Plasmodium falciparum cyclic amine resistance locus protein

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3074

Nomenclature: Plasmodium falciparum cyclic amine resistance locus protein

Abbreviated Name: PfCARL

Family: Transporters (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1283 CARL cyclic amine resistance locus protein
Previous and Unofficial Names Click here for help
PFC0970w
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Malaria Pharmacology Comments
The P. falciparum cyclic amine resistance locus (PfCARL) encodes a seven-transmembrane domain protein that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages [1]. Homology analysis provides an insight into possible function: the S. cerevisiae homolog, Emp65, is a part of a molecular chaperone complex in the endoplasmic reticulum and the mouse homolog, Tapt1, is involved in embryonic skeletal formation, signal transduction, and hormone trafficking [1,3].
Mutations in PfCARL are associated with parasite resistance to two distinct compound classes: the imidazolopiperazines, a novel class of antimalarial compounds that includes the clinical candidate ganaplacide, and the benzimidazolyl piperidines, with the suggestion that PfCARL is a multidrug-resistance gene rather than the common target [1-2].

References

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1. LaMonte G, Lim MY, Wree M, Reimer C, Nachon M, Corey V, Gedeck P, Plouffe D, Du A, Figueroa N et al.. (2016) Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance. MBio, 7 (4). [PMID:27381290]

2. Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. (2016) Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. ACS Infect Dis, 2 (11): 816-826. [PMID:27933786]

3. Zhang S, Xu C, Larrimore KE, Ng DTW. (2017) Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Cell, 171 (2): 346-357.e12. [PMID:28919078]

How to cite this page

Transporters (Plasmodium spp.): Plasmodium falciparum cyclic amine resistance locus protein. Last modified on 13/12/2021. Accessed on 24/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3074.