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Nucleoside synthesis and metabolism (Plasmodium spp.)


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During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.


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PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C Show summary » More detailed page go icon to follow link

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 23/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.