Nucleoside synthesis and metabolism (<i>Plasmodium</i> spp.) | Other protein targets

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Nucleoside synthesis and metabolism (Plasmodium spp.)

Nucleoside synthesis and metabolism (Plasmodium spp.)

Overview

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During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.

Targets

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2949
Nomenclature	Plasmodium falciparum dihydroorotate dehydrogenase
Common abbreviation	PfDHODH
Previous and unofficial names	DHODH \| Pf3D7_06_v3:130,191..132,792(-) \| DHOD \| PFF0160c
Genes	DHODH (Pf3D7)
UniProtKB AC	Q08210 (Pf3D7)
PlasmoDB	PF3D7_0603300 (Pf3D7)

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3077
Nomenclature	Plasmodium falciparum purine nucleoside phosphorylase
Common abbreviation	PfPNP
Previous and unofficial names	PNP \| Pf3D7_05_v3:568,594..570,527(-) \| PFE0660c
Genes	PNP (Pf3D7)
UniProtKB AC	Q8I3X4 (Pf3D7)
PlasmoDB	PF3D7_0513300 (Pf3D7)

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1060.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.